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Autophagy

Known as: Macroautophagy, autophagy/autophagia, Autophagies, Cellular 
A normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus… 
National Institutes of Health

Related topics

Related topics

50 relations
ATG13 geneATG13 wt AlleleATG16L1 protein, humanATG16L1 wt Allele

Broader (2)

Phagocytosiscytotoxicity

Narrower (2)

Programmed Cell Death, Type IIcellular catabolic process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Autophagy, Metabolism, and Cancer
Macroautophagy (autophagy hereafter) is a process that collects cytoplasmic components, particularly mitochondria, and degrades… 
Review
2012
Review
2012
Autophagy and cancer.
(Macro)autophagy is a cellular membrane trafficking process that serves to deliver cytoplasmic constituents to lysosomes for… 
Highly Cited
2011
Highly Cited
2011
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
Adult mouse LSK cells unable to undergo autophagy contain fewer HSCs, accumulate mitochondria, and fail to reconstitute lethally… 
Highly Cited
2009
Highly Cited
2009
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling
Autophagy is a highly conserved process that maintains homeostasis by clearing damaged organelles and long-lived proteins. The… 
Highly Cited
2007
Highly Cited
2007
ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation
Expanded polyglutamine 72 repeat (polyQ72) aggregates induce endoplasmic reticulum (ER) stress-mediated cell death with caspase… 
Highly Cited
2007
Highly Cited
2007
A critical role for the autophagy gene Atg5 in T cell survival and proliferation
Macroautophagy (hereafter referred to as autophagy) is a well-conserved intracellular degradation process. Recent studies… 
Review
2006
Review
2006
Autophagy in cancer: good, bad, or both?
Autophagy has been recognized as an important cellular process for at least 50 years; however, it is only with the recent… 
Highly Cited
2005
Highly Cited
2005
Lysosomal Turnover, but Not a Cellular Level, of Endogenous LC3 is a Marker for Autophagy
During starvation-induced autophagy in mammals, autophagosomes form and fuse with lysosomes, leading to the degradation of the… 
Review
2001
Review
2001
Ubiquitin and proteasomes: Molecular dissection of autophagy: two ubiquitin-like systems
Recent analyses of the genes required for autophagy ? intracellular bulk protein degradation ? in yeast have revealed two… 
Highly Cited
2001
Highly Cited
2001
Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway
The eIF2α kinases are a family of evolutionarily conserved serine/threonine kinases that regulate stress-induced translational… 
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