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Amino Acids and Insulin Control Autophagic Proteolysis through Different Signaling Pathways in Relation to mTOR in Isolated Rat Hepatocytes*
Autophagy, a major bulk proteolytic pathway, contributes to intracellular protein turnover, together with protein synthesis. Both are subject to dynamic control by amino acids and insulin. TheExpand
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Age-related changes in cholesterol and bile acid metabolism in rats.
Age-related changes in serum and liver cholesterol, phospholipid and triglyceride levels, serum lipoproteins, biliary secretion of cholesterol, phospholipid and bile acids, and fecal excretion ofExpand
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Autolysosomal Membrane-associated Betaine Homocysteine Methyltransferase
We compared the membrane proteins of autolysosomes isolated from leupeptin-administered rat liver with those of lysosomes. In addition to many polypeptides common to the two membranes, theExpand
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Effect of bile duct ligation on bile acid metabolism in rats.
The effect of bile duct ligation on the quantitative and qualitative changes of bile acids in serum, liver, urine, and feces, and the concentration of cholesterol and phospholipids in serum and liverExpand
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Multiphasic control of proteolysis by leucine and alanine in the isolated rat hepatocyte.
Autophagically mediated proteolysis in the perfused rat liver is under complex multiphasic control by a small group of amino acids dominated by leucine. Because there have been no prior reports ofExpand
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Effects of Rice Proteins from Two Cultivars, Koshihikari and Shunyo, on Hepatic Cholesterol Secretion by Isolated Perfused Livers of Rats Fed Cholesterol-Enriched Diets
Background/Aims: The aim of the present study was to clarify the effect of rice proteins, with different contents of glutelin and prolamin, on the regulation of hepatic cholesterol output pathwaysExpand
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Diversity of amino acid signaling pathways on autophagy regulation: a novel pathway for arginine.
Autophagy is the intracellular bulk degradation process to eliminate damaged cellular machinery and to recycle building blocks, and is crucial for cell survival and cell death. Amino acids modulateExpand
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Multiphasic control of hepatic protein degradation by regulatory amino acids. General features and hormonal modulation.
Previous studies with livers from fed rats perfused in the single-pass mode have shown that regulatory amino acids (Leu, Tyr, Gln, Pro, Met, His, and Trp) as a group as well as leucine alone inhibitExpand
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Altered bile acid metabolism in alloxan diabetic rats.
Changes of cholesterol, phospholipid, triglyceride or bile acid levels in serum liver, bile and feces after the treatment with alloxan were examined in Wistar strain male rats. Serum cholesterol,Expand
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Rice protein hydrolysates stimulate GLP-1 secretion, reduce GLP-1 degradation, and lower the glycemic response in rats.
Rice has historically been consumed in Asia as a major source of carbohydrates, however, little is known regarding the functional roles of rice proteins as dietary factors. In the present study, weExpand
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