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High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
These features of HMGB1 are discussed and recent advances that have led to the preclinical development of therapeutics that modulateHMGB1 release and activity are summarized. Expand
The Beclin 1 network regulates autophagy and apoptosis
New findings regarding the organization and function of the Beclin 1 network in cellular homeostasis are summarized, focusing on the cross-regulation between apoptosis and autophagy. Expand
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
It is demonstrated that HMGB1 is an early mediator of injury and inflammation in liver I/R and implicates TLR4 as one of the receptors that is involved in the process. Expand
A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone.
This immunotherapeutic approach can result in marked tumor regression in some patients for whom no other effective therapy is available at present, and determining its ultimate role in cancer therapy awaits further attempts to increase the therapeutic efficacy of treatment and decrease its toxicity and complexity. Expand
Endogenous HMGB1 regulates autophagy
HMGB1 displaces Bcl-2 from Beclin1 to induce and sustain autophagy in response to cell stress.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
PAMPs and DAMPs: signal 0s that spur autophagy and immunity
Recent advances in the understanding of autophagic molecular mechanisms and functions in emergent immunity are reviewed. Expand
Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer.
Preliminary results of the systemic administration of autologous lymphokine-activated killer (LAK) cells and the recombinant-derived lymphokin interleukin-2 to patients with advanced cancer are described, based on animal models in which this regimen mediated the regression of established pulmonary and hepatic metastases from a variety of murine tumors in several strains of mice. Expand
HMGB1 in health and disease.
High-mobility group box 1 (HMGB1), the most abundant and well-studied HMG protein, senses and coordinates the cellular stress response and plays a critical role not only inside of the cell as a DNA chaperone, chromosome guardian, autophagy sustainer, and protector from apoptotic cell death, but also outside thecell as the prototypic damage associated molecular pattern molecule (DAMP). Expand
The grateful dead: damage‐associated molecular pattern molecules and reduction/oxidation regulate immunity
It is speculated that their destruction through oxidative mechanisms normally exerted by myeloid cells, such as neutrophils and eosinophils, or their persistence in the setting of pathologic extracellular reducing environments, maintained by exuberant necrotic cell death and/or oxidoreductases, represent important molecular means enabling chronic inflammatory states. Expand