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The Beclin 1 network regulates autophagy and apoptosis
New findings regarding the organization and function of the Beclin 1 network in cellular homeostasis are summarized, focusing on the cross-regulation between apoptosis and autophagy. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Endogenous HMGB1 regulates autophagy
HMGB1 displaces Bcl-2 from Beclin1 to induce and sustain autophagy in response to cell stress.
PAMPs and DAMPs: signal 0s that spur autophagy and immunity
Recent advances in the understanding of autophagic molecular mechanisms and functions in emergent immunity are reviewed. Expand
HMGB1 in health and disease.
High-mobility group box 1 (HMGB1), the most abundant and well-studied HMG protein, senses and coordinates the cellular stress response and plays a critical role not only inside of the cell as a DNA chaperone, chromosome guardian, autophagy sustainer, and protector from apoptotic cell death, but also outside thecell as the prototypic damage associated molecular pattern molecule (DAMP). Expand
RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation
The Receptor for Advanced Glycation Endproducts [RAGE] is an evolutionarily recent member of the immunoglobulin super-family, encoded in the Class III region of the major histocompatability complex, and sits in a pivotal role, regulating metabolism, inflammation, and epithelial survival in the setting of stress. Expand
HMGB1 Release and Redox Regulates Autophagy and Apoptosis in Cancer Cells
It is shown that the high-mobility group box 1 protein (HMGB1) is a redox-sensitive regulator of the balance between autophagy and apoptosis, representing a suitable target when coupled with conventional tumor treatments. Expand
High-mobility group box 1 and cancer.
The studies suggest that HMGB1 is central to cancer (abnormal wound healing) and many of the findings in normal wound healing as well and therapeutic strategies based on targetingHMGB1 are suggested. Expand
Release and activity of histone in diseases
Elevated serum histone and nucleosome levels have been implicated in multiple pathophysiological processes and progression of diseases including autoimmune diseases, inflammatory diseases, and cancer and could serve as biomarkers and novel therapeutic targets in human diseases. Expand
Ferroptosis: process and function
Misregulated ferroptosis has been implicated in multiple physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, and T-cell immunity. Expand