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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the… Expand
Endogenous HMGB1 regulates autophagy
HMGB1 displaces Bcl-2 from Beclin1 to induce and sustain autophagy in response to cell stress.
PAMPs and DAMPs: signal 0s that spur autophagy and immunity
Pathogen‐associated molecular pattern molecules (PAMPs) are derived from microorganisms and recognized by pattern recognition receptor (PRR)‐bearing cells of the innate immune system as well as many… Expand
HMGB1 in health and disease.
- R. Kang, Ruochan Chen, +15 authors D. Tang
- Biology, Medicine
- Molecular aspects of medicine
- 1 December 2014
Complex genetic and physiological variations as well as environmental factors that drive emergence of chromosomal instability, development of unscheduled cell death, skewed differentiation, and… Expand
RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation
- L. J. Sparvero, Denise Asafu-Adjei, +8 authors M. Lotze
- Biology, Medicine
- Journal of Translational Medicine
- 17 March 2009
The Receptor for Advanced Glycation Endproducts [RAGE] is an evolutionarily recent member of the immunoglobulin super-family, encoded in the Class III region of the major histocompatability complex.… Expand
Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
Ferroptosis is a recently recognized form of regulated cell death caused by an iron‐dependent accumulation of lipid reactive oxygen species. However, the molecular mechanisms regulating ferroptosis… Expand
High-mobility group box 1, oxidative stress, and disease.
Oxidative stress and associated reactive oxygen species can modify lipids, proteins, carbohydrates, and nucleic acids, and induce the mitochondrial permeability transition, providing a signal leading… Expand
Release and activity of histone in diseases
Histones and their post-translational modifications have key roles in chromatin remodeling and gene transcription. Besides intranuclear functions, histones act as damage-associated molecular pattern… Expand
HMGB1 Release and Redox Regulates Autophagy and Apoptosis in Cancer Cells
The functional relationship and cross-regulation between autophagy and apoptosis is complex. In this study we show that the high-mobility group box 1 protein (HMGB1) is a redox-sensitive regulator of… Expand
High-mobility group box 1 and cancer.
High-mobility group box 1 protein (HMGB1), a chromatin associated nuclear protein and extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily ancient and critical… Expand