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Physical chemistry : a molecular approach
The Dawn of Quantum Theory Classical Wave Equation Schrodinger Equation Principles of Quantum Mechanics Harmonic Oscillator and Rigid Rotator Hydrogen Atom Approximation Methods Multielectron Atoms…
Melanins and melanogenesis: methods, standards, protocols
The aim of the paper was to define an unprecedented frame of reference built on cutting‐edge knowledge and state‐of‐the‐art methodology, to enable reliable comparison of results among laboratories and new progress in the field based on standardized methods and shared information.
Direct chemical evidence for eumelanin pigment from the Jurassic period
- Keely E Glass, S. Ito, J. Simon
- Environmental ScienceProceedings of the National Academy of Sciences
- 21 May 2012
Direct chemical techniques are applied to categorically demonstrate the preservation of eumelanin in two > 160 Ma Jurassic cephalopod ink sacs and to confirm its chemical similarity to the ink of the modern cepHalopod, Sepia officinalis.
Ultrastructural organization of eumelanin from Sepia officinalis measured by atomic force microscopy.
Atomic force microscopy data provides strong supporting evidence for the conclusion that eumelanin is comprised of small oligomersic units and that the structural morphology observed in imaging experiments reflects aggregation of these oligomeric molecules.
Current challenges in understanding melanogenesis: bridging chemistry, biological control, morphology, and function
This review examines the current understanding of the initial chemical steps in the melanogenesis and focuses on the mixed melanin systems, with a critical eye towards understanding how studies on individual melanin do and do not provide insight in the molecular aspects of their structures.
Ion-exchange and adsorption of Fe(III) by Sepia melanin.
The natural concentrations of metal ions are presented and the ability to remove metals by exposure of the melanin granules to EDTA is quantified and the binding of Fe(III) is concluded to involve coordination to o-dihydroxyl groups.
Insights into melanosomes and melanin from some interesting spatial and temporal properties.
Recent work using surface-sensitive analytic, spectroscopic, and imaging techniques to examine the structural and chemical properties of many types of natural pigments: sepia melanin granules, human and bovine ocular melanosomes, human hair melanosome, and neuromelanin is discussed.
Melanins and melanogenesis: from pigment cells to human health and technological applications
An interdisciplinary perspective of melanin pigments and related pathway is provided with a view to showing how it is possible to translate current knowledge about physical and chemical properties and control mechanisms into new bioinspired solutions for biomedical, dermocosmetic, and technological applications.
Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease
- D. Sulzer, E. Mosharov, Z. Tallóczy, F. Zucca, J. Simon, L. Zecca
- Biology, MedicineJournal of Neurochemistry
- 1 July 2008
The most striking morphologic change in neurons during normal aging is the accumulation of autophagic vacuoles filled with lipofuscin or neuromelanin pigments, which may eventually interfere with normal degradative pathways and endocytic/secretory tasks such as appropriate response to growth factors.
Current understanding of the binding sites, capacity, affinity, and biological significance of metals in melanin.
The current state of understanding of metal binding plays in determining the physical, structural, biological, and photochemical properties of melanin is examined.