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Aldehyde Reductase

Known as: Alditol:NAD(P)+ 1-oxidoreductase, Reductase, Aldose, Aldose Reductase 
An enzyme that catalyzes reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses. EC 1.1.1.21.
National Institutes of Health

Related topics

Related topics

20 relations
AKR1A1 geneAKR1B1 geneIn BloodProcess of secretion

Narrower (10)

AKR1A1 protein, humanAKR7A1Akr1b7 protein, mouseErythrose Reductase

Broader (1)

Alcohol Oxidoreductases

Papers overview

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Highly Cited
1998
Highly Cited
1998
Comparative study of seventeen Salvia plants: aldose reductase inhibitory activity of water and MeOH extracts and liquid chromatography-mass spectrometry (LC-MS) analysis of water extracts.
The dry root and rhizome of Salvia miltiorhiza (Lamiaceae) are used as a crude drug Danshen, while those of S. deserta (Xinjiang… 
Highly Cited
1989
Highly Cited
1989
Signal for induction of aldose reductase in renal medullary cells by high external NaCl.
GRB-PAP1 is a continuous line of epithelial cells derived from rabbit renal inner medulla. These cells accumulate large amounts… 
Highly Cited
1987
Highly Cited
1987
Effects of Experimental Diabetes, Uremia, and Malnutrition on Wound Healing
The strength of linear wounds was studied in normal and diabetic rats in the first 8 wk after wounding. The strength of wounds… 
Highly Cited
1986
Highly Cited
1986
Prevention of Basement Membrane Thickening in Retinal Capillaries by a Novel Inhibitor of Aldose Reductase, Tolrestat
A diabetic-like thickening of retinal capillary basement membranes induced in rats fed for 207 consecutive days a diet containing… 
Highly Cited
1983
Highly Cited
1983
The Effect of an Aldose Reductase Inhibitor (Sorbinil) on the Level of Metabolites in Lenses of Diabetic Rats
This study examined the effect of an aldose reductase inhibitor (Sorbinil, CP 45634,Pfizer, Sandwich, Kent, United Kingdom) on… 
Highly Cited
1982
Highly Cited
1982
Galactose cataract prevention with sorbinil, an aldose reductase inhibitor: a light microscopic study.
Cataract formation in galactosemic rats was studied by ophthalmoscopy, slit-lamp biomicroscopy, and by light microscopy using… 
Highly Cited
1979
Highly Cited
1979
CP-45,634: a novel aldose reductase inhibitor that inhibits polyol pathway activity in diabetic and galactosemic rats.
Highly Cited
1977
Highly Cited
1977
Aldose reductase in retinal mural cells.
Cultured mural cells (intramural pericytes) from adult rhesus retinal capillaries were examined for the presence of the sorbitol… 
Highly Cited
1969
Highly Cited
1969
A biochemical evaluation of a cataract induced in a high-glucose medium.
Rabbit lenses were incubated in lowand high-glucose media in an attempt to evaluate the role of the sorbitol pathway in the… 
Highly Cited
1968
Highly Cited
1968
The Sorbitol Pathway: Enzyme Localization and Content in Normal and Diabetic Nerve and Cord
The enzymes of the sorbitol pathway, aldose reductase and sorbitol dehydrogenase, were investigated in sciatic nerve and spinal… 
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