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Cellular response to hyperosmotic stresses.
TLDR
The facts that numerous cellular functions are altered by hyperosmolality and remain so, even after adaptation, indicate that both the effects of hyperos molality and adaptation to it involve profound alterations of the state of the cells. Expand
Function of the thick ascending limb of Henle's loop.
  • M. Burg, N. Green
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 March 1973
TLDR
Water permeability (Lp) is low, which combined with the NaCl transport accounts for the dilution of the urine in this segment, and Na permeability is greater than Cl permeability, as indicated by radioisotope measurements of ion fluxes. Expand
Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein.
TLDR
Transporter mRNA is present in kidney and brain and is markedly induced in MDCK cells by medium hypertonicity, demonstrating that adaptation to hypertonic stress involves up-regulation of transporter mRNA accumulation. Expand
Cloning of a Na(+)- and Cl(-)-dependent betaine transporter that is regulated by hypertonicity.
TLDR
Expression in oocytes indicates that the renal BGT-1 protein has both betaine and GABA transport activities that are Cl(-)- as well as Na(+)-dependent and functionally similar to betaineand GABA transport in MDCK cells. Expand
Regulation of gene expression by hypertonicity.
TLDR
This review considers how solutes help relieve the stress of hypertonicity and the nature of transporters and enzymes responsible for their variable accumulation and the molecular basis for osmotic regulation of these genes. Expand
Renal medullary organic osmolytes.
TLDR
Normal organic osmolyte regulation contributes to the survival and growth of medullary cells in their hyperosmolal environment, and defective regulation can damage them. Expand
Molecular basis of osmotic regulation.
  • M. Burg
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 June 1995
TLDR
Osmotic regulation of inositol and taurine uptake also involves increased expression of specific transporter genes, and GPC is unique in that its level rises in response to high urea, as well as hypertonicity. Expand
Intracellular Organic Osmolytes: Function and Regulation*
TLDR
This review discusses how the organic osmolytes protect, the identity of o smolytes in Archaea, bacteria, yeast, plants, marine animals, and mammals, the mechanisms by which they are accumulated, and the signaling pathways involved. Expand
Furosemide effect on isolated perfused tubules.
TLDR
The principal renal action of this drug is to inhibit active Cl transport in the thick ascending limb of Henle's loop with resultant decrease in net NaCl absorption and electrical PD. Expand
Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.
TLDR
It is demonstrated that an effective immune response against primary prostate tumors in transgenic (TRAMP) mice can be elicited using a strategy that combines CTLA-4 blockade and an irradiated tumor cell vaccine, and suggest potential of this approach for treatment of prostate cancer. Expand
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