ISOLATION AND PROPERTIES OF LENS ALDOSE REDUCTASE.
- S. Hayman, J. Kinoshita
- Biology, MedicineJournal of Biological Chemistry
- 1 February 1965
A thirty year journey in the polyol pathway.
- J. Kinoshita
- Medicine, BiologyExperimental Eye Research
- 1 June 1990
Mechanisms initiating cataract formation. Proctor Lecture.
- J. Kinoshita
- Medicine, BiologyInvestigative Ophthalmology
- 1 October 1974
In the hereditary mouse cataract, the imbalance of the pump-leak system appears to be initiated by a deficiency of Na-K ATPase, a component of the cation pump mechanism, which results in osmotic swelling.
Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor.
- W. Robison, P. Kador, J. Kinoshita
- Medicine, BiologyScience
- 16 September 1983
A twofold thickening of capillary basement membranes of rat retinas resulting from dietary galactose was prevented by sorbinil, an inhibitor of aldose reductase, which may indicate changes in vessel permeability and susceptibility to hemorrhage.
Flavonoids as inhibitors of lens aldose reductase.
- S. Varma, I. Mikuni, J. Kinoshita
- BiologyScience
- 20 June 1975
Quercetin, quercitrin, and myricitrin are significantly more potent than the previously known aldose reductase inhibitors and effectively blocks polyol accumulation in intact rat lenses incubated in medium containing high concentration of sugars.
FACTORS AFFECTING THE FORMATION OF SUGAR ALCOHOLS IN OCULAR LENS.
- J. Kinoshita, S. Futterman, K. Satoh, L. Merola
- Biology, ChemistryBiochimica et Biophysica Acta
- 1963
Aldose reductase in the diabetic eye. XLIII Edward Jackson memorial lecture.
- J. Kinoshita
- MedicineAmerican journal of ophthalmology-glaucoma
- 1 December 1986
The pharmacology of aldose reductase inhibitors.
- P. Kador, W. Robison, J. Kinoshita
- BiologyAnnual Review of Pharmacology and Toxicology
- 1985
Polyol Accumulation in Galactosemic and Diabetic Rats: Control by an Aldose Reductase Inhibitor
- D. Dvornik, N. Simard-Duquesne, L. Merola
- Biology, ChemistryScience
- 14 December 1973
An orally active inhibitor of aldose reductase, 1,3-dioxo-1H-benz[de]-isoquinoline-2(3H)acetic acid (AY-22,284), prevented cataractous changes in cultured lenses exposed to high concentrations of…
The involvement of aldose reductase in diabetic complications.
- J. Kinoshita, C. Nishimura
- MedicineDiabetes Metabolism Reviews
- 1 June 1988
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