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AKR7A1

Known as: aldehyde reductase AKR7A1 
 
National Institutes of Health

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Related topics

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Broader (1)

Aldehyde Reductase

Papers overview

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2011
2011
Aldo‐keto reductase‐7A protects liver cells and tissues from acetaminophen‐induced oxidative stress and hepatotoxicity
Aldo‐keto reductase‐7A (AKR7A) is an enzyme important for bioactivation and biodetoxification. Previous studies suggested that… Expand
2009
2009
Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat.
In both experimental animals and humans, aflatoxin B(1) (AFB(1)) is a potent hepatic toxin and carcinogen against which a variety… Expand
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2008
2008
Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3.
The reduction of the aflatoxin B 1 (AFB 1) dialdehyde metabolite to its corresponding mono and dialcohols, catalyzed by aflatoxin… Expand
2004
2004
Detoxication of the environmental pollutant acrolein by a rat liver aldo-keto reductase.
Acrolein is a highly reactive hazardous air pollutant of human health concern, particularly as it is a component of cigarette… Expand
2003
2003
Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene…
Rat aflatoxin B(1) aldehyde reductase (called AFAR1 or AKR7A1) is a member of the aldo-keto reductase 7 family, which metabolizes… Expand
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2003
2003
The high resolution crystal structure of rat liver AKR7A1: understanding the substrate specificites of the AKR7 family.
The structure of the rat liver aflatoxin dialdehyde reductase (AKR7A1) has been solved to 1.38 A resolution. The crystal… Expand
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2002
2002
The Crystal Structure of Rat Liver AKR7A1
The structure of the rat liver aflatoxin dialdehyde reductase (AKR7A1) has been solved to 1.38-Å resolution. Although it shares a… Expand
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2002
2002
Characterisation of a novel mouse liver aldo‐keto reductase AKR7A5
We have characterised a novel aldo‐keto reductase (AKR7A5) from mouse liver that is 78% identical to rat aflatoxin dialdehyde… Expand
2001
2001
Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility.
The regulation of the aldo-keto reductase AKR7A1 was examined in the livers of male and female rats during development by using… Expand
Highly Cited
1999
Highly Cited
1999
cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3.
The aflatoxin B1 (AFB1) aldehyde metabolite of AFB1 may contribute to the cytotoxicity of this hepatocarcinogen via protein… Expand
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