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AKR7A1

Known as: aldehyde reductase AKR7A1 
National Institutes of Health

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Broader (1)

Aldehyde Reductase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Aldo‐keto reductase‐7A protects liver cells and tissues from acetaminophen‐induced oxidative stress and hepatotoxicity
Aldo‐keto reductase‐7A (AKR7A) is an enzyme important for bioactivation and biodetoxification. Previous studies suggested that… 
2009
2009
Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat.
In both experimental animals and humans, aflatoxin B(1) (AFB(1)) is a potent hepatic toxin and carcinogen against which a variety… 
2008
2008
Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3.
The reduction of the aflatoxin B 1 (AFB 1) dialdehyde metabolite to its corresponding mono and dialcohols, catalyzed by aflatoxin… 
2008
2008
Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis.
2004
2004
Detoxication of the environmental pollutant acrolein by a rat liver aldo-keto reductase.
2003
2003
Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene…
Rat aflatoxin B(1) aldehyde reductase (called AFAR1 or AKR7A1) is a member of the aldo-keto reductase 7 family, which metabolizes… 
2003
2003
Substrate specificity of mouse aldo-keto reductase AKR7A5.
2002
2002
Characterisation of a novel mouse liver aldo‐keto reductase AKR7A5
2002
2002
The Crystal Structure of Rat Liver AKR7A1
The structure of the rat liver aflatoxin dialdehyde reductase (AKR7A1) has been solved to 1.38-Å resolution. Although it shares a… 
Highly Cited
1999
Highly Cited
1999
cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3.
The aflatoxin B1 (AFB1) aldehyde metabolite of AFB1 may contribute to the cytotoxicity of this hepatocarcinogen via protein… 
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