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AKR1B1 gene

Known as: ALDR1, ALDOSE REDUCTASE, AKR1B1 
National Institutes of Health

Related topics

Related topics

7 relations
AR geneAldehyde ReductaseAndrogen ReceptorBulbo-Spinal Atrophy, X-Linked

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages.
Highly Cited
2006
Highly Cited
2006
Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells.
The objective of this study was to determine whether the polyol pathway enzyme aldose reductase mediates diabetes abnormalities… 
2006
2006
Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells.
PURPOSE Bacterial infections are one of the major causes of human eye disease. Because the bacterial endotoxin lipopolysaccharide… 
2002
2002
Polymorphisms and functions of the aldose reductase gene 5' regulatory region in Chinese patients with type 2 diabetes mellitus.
OBJECTIVE To screen the 5' regulatory region of the aldose reductase (AR) gene for genetic variabilities causing changes in… 
Highly Cited
1998
Highly Cited
1998
Aldose reductase inhibition improves altered glucose metabolism of isolated diabetic rat hearts.
Alterations in glucose metabolism have been implicated in the cardiovascular complications of diabetes. Previous work in this… 
Highly Cited
1995
Highly Cited
1995
Tissue-specific expression of two aldose reductase-like genes in mice: abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal gland.
Aldose reductase (AR), the first enzyme in the polyol pathway, has been implicated in the pathogenesis of diabetic complications… 
1992
1992
Maturation of aldose reductase expression in the neonatal rat inner medulla.
Newborns are less able to concentrate urine than adults are. With development of the concentrating system and a hypertonic… 
1991
1991
Tissue-Specific Effects of Aldose Reductase Inhibition on Fluorescence and Cross-Linking of Extracellular Matrix in Chronic Galactosemia: Relationship to Pentosidine Cross-Links
Chronic experimental hyperglycemia mediated by galactose has been shown to induce browning and cross-linking of rat tail tendon… 
Highly Cited
1990
Highly Cited
1990
Effects of Long-Term Aldose Reductase Inhibition on Development of Experimental Diabetic Neuropathy: Ultrastructural and Morphometric Studies of Sural Nerve in Streptozocin-Induced Diabetic Rats
There is controversy over the efficacy of aldose reductase inhibitors in preventing the development of peripheral nerve lesions… 
Highly Cited
1989
Highly Cited
1989
Aldose reductase from human psoas muscle. Purification, substrate specificity, immunological characterization, and effect of drugs and inhibitors.
Aldose reductase (ALR2) has been purified to homogeneity from human psoas muscle. From sodium dodecyl sulfate-polyacrylamide… 
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