Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

AKR1B1 gene

Known as: ALDR1, ALDOSE REDUCTASE, AKR1B1 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
The aldo-keto reductase (AKR) protein superfamily contains >190 members that fall into 16 families and are found in all phyla… Expand
Is this relevant?
Highly Cited
2008
Highly Cited
2008
As part of our ongoing search of natural sources for therapeutic and preventive agents for diabetic complications, the rat lens… Expand
  • table I
  • figure 1
  • table II
  • table III
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Retinopathy is a major cause of blindness in the Western world, while cataract is one of the three major causes of blindness… Expand
Is this relevant?
Highly Cited
2004
Highly Cited
2004
PURPOSE Aldose reductase (AR) has been a drug target because of its involvement in the development of secondary complications of… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Aldose reductase, the key enzyme of the polyol pathway, and oxidative stress are known to play important roles in the… Expand
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Objective: To determine whether the aldose reductase inhibitor (ARI) zenarestat improves nerve conduction velocity (NCV) and… Expand
  • figure 1
  • figure 2
  • table 3
  • table 4
  • figure 3
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Diabetes increases the incidence of cardiovascular disease as well as the complications of myocardial infarction. Studies using… Expand
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Hydrogen peroxide (H2O2) or 4-hydroxy-2,3-trans-nonenal (HNE) treatment of rat vascular smooth muscle cells (A7r5) caused… Expand
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Rats developed tactile allodynia within days of the onset of diabetes and which persisted for up to 8 weeks. Allodynia was… Expand
Is this relevant?
Highly Cited
1995
Highly Cited
1995
SummaryAdvanced glycation is an important pathogenic mechanism in the development of diabetic complications. However, other… Expand
  • table 1
  • figure 3
  • figure 4
Is this relevant?