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The evolution of prostate cancer from an androgen-dependent state to one that is androgen-independent marks its lethal… Expand The normal development and maintenance of the prostate is dependent on androgen acting through the androgen receptor (AR). AR… Expand Androgen receptor (AR) is a member of the steroid hormone receptor family of molecules. AR primarily is responsible for mediating… Expand The biological action of androgens is mediated through the androgen receptor (AR). Androgen-bound AR functions as a transcription… Expand Androgen receptor (AR) is required for sexual differentiation and is implicated in the development of prostate cancer. Here we… Expand The relationship of the classical receptors and their transcriptional activity to nongenotropic effects of steroid hormones is… Expand The development and growth of prostate cancer depends on the androgen receptor and its high-affinity binding of… Expand BACKGROUND
Metastatic prostate cancer is a leading cause of cancer-related death in men. The rate of response to androgen… Expand THE increase in the number of reports of abnormalities in male sex development in wildlife and humans coincided with the… Expand The androgen receptor (AR) mediates the actions of male sex steroids. Human AR genomic DNA was cloned from a flow-sorted human X… Expand