• Publications
  • Influence
Modulation of endocrine systems and food intake by green tea epigallocatechin gallate.
Endocrine changes induced by parenteral administration of EGCG may relate to the observed growth inhibition and regression of human prostate and breast tumors in athymic mice treated with E GCG as well as play a role in the mechanism by which EGCGs inhibits cancer initiation and promotion in various animal models of cancer.
Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest.
It is concluded that androgenic repression of LNCaP 104-R1 and104-R2 cell proliferation is due to the induction of p27Kip1, which in turn inhibits Cdk2, a factor critical for cell cycle progression and proliferation.
Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate.
Intraperitoneal injection of green tea (-)epigallocatechin-3-gallate but not structurally related catechins inhibited the growth and rapidly reduced the size of human prostate tumors in nude mice, and it is possible that there is a relationship between the high consumption of greenTea and the low incidence of prostate and breast cancers in some Asian countries.
Green tea: biochemical and biological basis for health benefits.
Evidence based on modern scientific evaluations of green tea appears to support the possibility that green tea compounds, especially catechins, are medically valuable, and it is discussed that tea polyphenols are widely used as natural antioxidants for prevention of oxidation of edible oils or discoloring of foods.
Human prostate tumor growth in athymic mice: inhibition by androgens and stimulation by finasteride.
It is shown that androgen supplementation therapy may be beneficial for treatment of certain types of human prostate cancer and that the use of 5 alpha-reductase inhibitors, such as finasteride or anti-androgens, in the general treatment of metastatic prostate cancer may require careful assessment.
Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids.
Human or rat microsomal 5 alpha-reductase activity, as measured by enzymic conversion of testosterone into 5 alpha-dihydrotestosterone or by binding of a competitive inhibitor, [3H]17
Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors.
The cDNA for a member of the nuclear receptor family was cloned and named ubiquitous receptor (UR), since UR protein and mRNA are detected in many cell types. Rat UR/human retinoid X receptor alpha
Prostatic ductal system in rats: regional variation in morphological and functional activities.
There was a reversal in the site of programmed death in cells lining the ductal system following castration in adult rats, and distal segments contained many epithelial cells with intense cytoplasmic staining for cathepsin D while proximal segments showed a reduction in number of positively stained cells.
Enzymatic oxidation of some non-phosphorylated derivatives of dihydronicotinamide.
The purified enzyme catalyzes the oxidation of certain N1-alkyl-dihydronicotinamides, but it is completely inert toward phosphorylated derivatives of dihydronicotinamide such as the reduced forms of nicotinamide mononucleotide, and of di- and triphosphopyridine nucleotides (DPNH and TPNH).
Steroid structure and androgenic activity. Specificities involved in the receptor binding and nuclear retention of various androgens.
It is found that many potent synthetic androgens can bind directly to β protein and to prostate cell nuclei without a metabolic conversion, indicating that the bulkiness and flatness of the steroid molecule play a more important role in receptor binding than the detailed electronic structure at the Δ4 bond of Ring A.