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Androgen receptor defects : Historical, clinical, and molecular perspectives
TLDR
AIS is an archetypal example of a hormone resistance disorder; however, due to defective androgen receptor (AR1) function, there is loss of target organ response to the hormone, and the effects of androgens are reduced or absent.
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Androgen receptor defects: historical, clinical, and molecular perspectives.
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The Androgen Axis in Recurrent Prostate Cancer
TLDR
Novel therapies for recurrent prostate cancer should target androgen receptor directly and prevent the formation of androgens within prostate cancer tissue at levels sufficient to activate androgenceptor.
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Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen.
TLDR
The results suggest that AR is transcriptionally active in recurrent CaP and can increase cell proliferation at the low circulating levels of androgen reported in castrated men.
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A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy.
TLDR
A majority of recurrent prostate cancers express high levels of the androgen receptor and two nuclear receptor coactivators, transcriptional intermediary factor 2 and steroid receptors coactivator 1, and this work provides a molecular basis for this activation and suggests a general mechanism for recurrent prostate cancer growth.
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Cloning of human androgen receptor complementary DNA and localization to the X chromosome.
TLDR
The deduced amino acid sequence of AR within the DNA-binding domain has highest sequence identity with the progesterone receptor.
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Transcriptional activation and nuclear targeting signals of the human androgen receptor.
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Androgen receptor expression in androgen-independent prostate cancer is associated with increased expression of androgen-regulated genes.
TLDR
Investigation of human prostate cancer xenograft CWR22 found androgen regulation of alpha-enolase and alpha-tubulin as well as other unknown mRNAs, including Insulin-like growth factor binding protein-5, the homeobox gene Nkx 3.1, the AR coactivator ARA-70, and cell cycle genes Cdk1 and Cdk2 were androgen regulated in C WR22.
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The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate.
TLDR
Cl cloning of the complete coding sequence of the human androgen receptor (hAR) reveals identical sequences in the DNA- and hormone-binding domains, with an overall homology of 85%.
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Site-specific Androgen Receptor Serine Phosphorylation Linked to Epidermal Growth Factor-dependent Growth of Castration-recurrent Prostate Cancer*
TLDR
The results support a model in which AR transcriptional activity increases castration-recurrent prostate cancer cell growth in response to EGF by site-specific serine phosphorylation that regulates nuclear-cytoplasmic shuttling through interactions with the Ku-70/80 regulatory complex.
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