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The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
By integrating RNA interference–mediated depletion of Oct4 and Nanog with microarray expression profiling, it is demonstrated that these factors can activate or suppress transcription, and it is shown that common core downstream targets are important to keep ES cells from differentiating. Expand
A Pattern-Based Method for the Identification of MicroRNA Binding Sites and Their Corresponding Heteroduplexes
We present rna22, a method for identifying microRNA binding sites and their corresponding heteroduplexes. Rna22 does not rely upon cross-species conservation, is resilient to noise, and, unlike… Expand
A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome
A robust approach is described that couples chromatin immunoprecipitation (ChIP) with the paired-end ditag (PET) sequencing strategy for unbiased and precise global localization of transcription-factor binding sites (TFBS). Expand
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1
It is demonstrated that Sall4 is a transcriptional activator of Pou5f1 and has a critical role in the maintenance of ES cell pluripotency by modulating Oct4 expression, and indicates that SAll4 is important for early embryonic cell-fate decisions. Expand
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation
The findings demonstrate the abundance of CDS-located miRNA targets, some of which can be species-specific, and support an augmented model whereby animal miRNAs exercise their control on mRNAs through targets that can reside beyond the 3′ untranslated region. Expand
MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity
The remarkable inverse regulatory pattern for many miRNAs during adipogenesis and obesity has important implications for understanding adipose tissue dysfunction in obese mice and humans and the link between chronic inflammation and obesity with insulin resistance. Expand
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb
This work shows that the orphan nuclear receptor Esrrb functions in conjunction with Oct4 and Sox2 to mediate reprogramming of mouse embryonic fibroblasts (MEFs) to iPS cells, and indicates that it is possible to reprogram MEFs without exogenous Klf transcription factors and link a nuclear receptor to somatic cell reprograming. Expand
Sall4 Interacts with Nanog and Co-occupies Nanog Genomic Sites in Embryonic Stem Cells*
It is suggested that Sall4 and Nanog form a regulatory circuit similar to that of Oct4 and Sox2, which encode for key transcription factors in ES cells by cooperating with Nanog. Expand
MicroRNA-125b is a novel negative regulator of p53.
It is demonstrated that miR-125b, a brain-enriched microRNA, is a bona fide negative regulator of p53 in both zebrafish and humans and demonstrates that p53 gene expression is tightly regulated during development and during the stress response. Expand
Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression.
The data identify the signaling mechanisms by which RA can affect both Treg cell and Th17 differentiation, and highlight that in vivo during an autoimmune reaction, RA suppresses autoimmunity mainly by inhibiting the generation of effector Th17 cells. Expand