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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.
TLDR
Amplification of the HER-2/neu gene was a significant predictor of both overall survival and time to relapse in patients with breast cancer, and had greater prognostic value than most currently used prognostic factors in lymph node-positive disease.
Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer.
BACKGROUND The p53 (also known as TP53) tumor suppressor gene encodes for a nuclear phosphoprotein thought to regulate proliferation of normal cells. Most p53 mutations result in a nonfunctional
Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen.
TLDR
Tamoxifen is found to have dual dose-dependent estrogenic/antiestrogenic properties and the action of the antiestrogen nafoxidine is not biphasic in MCF-7 cells; it does not induce PgR over a wide dose range and at high doses, the compound inhibits cell growth.
Biological and Clinical Implications of Heat Shock Protein 27000 (Hsp27): a Review
TLDR
Studies suggest, however, that detection of Hsp27 should not be considered to be a method for identifying hormone-responsive tumors or detecting estrogen receptors, and HSP27 and other Hsps may be active in development of resistance to stressful conditions and agents including cytotoxic drugs.
Steroid receptor analyses of nine human breast cancer cell lines.
TLDR
It is found that estrogen receptor is usually localized in the nucleus as unfilled nuclear estrogen receptor and progesterone receptor differed, suggesting that these proteins are dissimilar.
Prediction of relapse or survival in patients with node-negative breast cancer by DNA flow cytometry.
TLDR
It is concluded that DNA flow-cytometric measurements of ploidy and S-phase fraction can be performed on frozen specimens of tumors and are potentially important predictors of disease-free and overall survival in patients with node-negative breast cancer.
Survival from first recurrence: relative importance of prognostic factors in 1,015 breast cancer patients.
TLDR
Both estrogen receptor (ER) status and axillary lymph node status at diagnosis, as well as the length of the disease-free interval, provide additional independent information for predicting patient survival after disease recurrence.
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