Teerawat Monnor

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Aromatase, a rate-limiting enzyme catalyzing the conversion of androgen to estrogen, is overexpressed in human breast cancer tissue. Aromatase inhibitors (AIs) have been used for the treatment of estrogen-dependent breast cancer in post-menopausal women by blocking the biosynthesis of estrogen. The undesirable side effects in current AIs have called for(More)
A data set of 1-adamantylthiopyridine analogs (1-19) with antioxidant activity, comprising of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide dismutase (SOD) activities, was used for constructing quantitative structure-activity relationship (QSAR) models. Molecular structures were geometrically optimized at B3LYP/6-31g(d) level and subjected for further(More)
BACKGROUND The aim of this study is to explore the relationship between hematological parameters and glycemic status in the establishment of quantitative population-health relationship (QPHR) model for identifying individuals with or without diabetes mellitus (DM). METHODS A cross-sectional investigation of 190 participants residing in Nakhon Pathom,(More)
This study explores the chemical space and quantitative structure-activity relationship (QSAR) of a set of 60 sulfonylpyridazinones with aldose reductase inhibitory activity. The physicochemical properties of the investigated compounds were described by a total of 3230 descriptors comprising of 6 quantum chemical descriptors and 3224 molecular descriptors.(More)
This study represents the first large-scale study on the chemical space of inhibitors of dipeptidyl peptidase-4 (DPP4), which is a potential therapeutic protein target for the treatment of diabetes mellitus. Herein, a large set of 2,937 compounds evaluated for their ability to inhibit DPP4 was compiled from the literature. Molecular descriptors were(More)
—In this work, Preisach model was used to study dynamic hysteresis properties. The patterns of nonlinear relay operators, the hysterons, with sizes of 2020 hysterons were varied to construct hysteresis loops. The simulation results show that the homogeneous scatter of hysteron results in the symmetric hysteresis loop. On the other hand, the inhomogeneous(More)
Neural correlations in the electrosensory lateral line lobe of the weakly electric fish, Apteronotus leptorhynchus: analysis of multi-channel recordings It is recognized that perception and behavior result from the activities of large neural ensembles. As such, it is key to understand the mechanisms that give rise to correlated activity in the brain.(More)
It is generally known that proliferation of human breast cancer cells is stimulated by excess estrogen namely 17β-estradiol. Therefore, reduction of 17β-estradiol production by inhibiting 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is an interesting route for breast cancer treatment particularly during adjuvant therapy. This study investigated the(More)
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