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AKR1A1 gene

Known as: ALR, ALDEHYDE REDUCTASE, AKR1A1 
This gene plays a role in the reduction of biogenic and xenobiotic aldehydes.
National Institutes of Health

Related topics

Related topics

6 relations
AKR1A1 protein, humanAKR1C3 geneAKR1C3 wt AlleleAldehyde Reductase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Pharmacokinetic interactions of breast cancer chemotherapeutics with human doxorubicin reductases.
2013
2013
Evaluation of the prostaglandin F synthase activity of human and bovine aldo-keto reductases: AKR1A1s complement AKR1B1s as potent PGF synthases.
2012
2012
Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1.
2012
2012
Benzo(a)pyrene induces hepatic AKR1A1 mRNA expression in tilapia fish (Oreochromis niloticus)
AKR1A1 or aldehyde reductase is a member of the aldo-keto reductases superfamily that is evolutionarily conserved among species… 
2011
2011
The role of aldehyde reductase AKR1A1 in the metabolism of γ-hydroxybutyrate in 1321N1 human astrocytoma cells.
2008
2008
Two Allelic Variants of Aldo-Keto Reductase 1A1 Exhibit Reduced in Vitro Metabolism of Daunorubicin
Aldo-keto reductases (AKRs) are a class of NADPH-dependent oxidoreductases that have been linked to metabolism of the… 
2008
2008
Aldo-Keto Reductase 1C2 Fails to Metabolize Doxorubicin and Daunorubicin in Vitro
The anthracycline drugs are important for the treatment of a number of malignancies; however, their clinical use is associated… 
2007
2007
Specifically Immobilised Aldo/Keto Reductase AKR1A1 Shows a Dramatic Increase in Activity Relative to the Randomly Immobilised Enzyme
The difference between site‐specific and random immobilisation of the aldo/keto reductase AKR1A1 was explored. AKR1A1 was… 
2007
2007
Benzo[a]pyrene-7,8-dihydrodiol Promotes Checkpoint Activation and G2/M Arrest in Human Bronchoalveolar Carcinoma H358 Cells
Polycyclic aromatic hydrocarbons (PAHs) are potent carcinogens that require metabolic activation inside cells. The proximate… 
2006
2006
Competing roles of aldo-keto reductase 1A1 and cytochrome P4501B1 in benzo[a]pyrene-7,8-diol activation in human bronchoalveolar H358 cells: role of AKRs in P4501B1 induction.
Benzo[a]pyrene (BP) requires metabolic activation to electrophiles to exert its deleterious effects. We compared the respective… 
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