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Chronic Arsenic Poisoning in the North of Mexico
TLDR
Non-specific symptoms were more prevalent in the exposed population and they occurred more frequently in those individuals with skin signs, and the relative risk of suffering a particular manifestation of poisoning, ranged from 1.9 to 36 times higher in the exposure population. Expand
Cytogenetic effects in human exposure to arsenic.
TLDR
The type of cytogenetic damage observed gives evidence of arsenic as a clastogenic/aneugenic carcinogen in rural populations that live in the same geographical area and have similar socioeconomic status, but different degree of exposure to inorganic arsenic via drinking water. Expand
Stress proteins induced by arsenic.
TLDR
A critical review of the capacity of arsenicals to modulate the expression and/or accumulation of stress proteins is offered, finding that the stress response appears to be useful to monitor the sublethal toxicity resulting from a single exposure to arsenite. Expand
Chlorzoxazone, a selective probe for phenotyping CYP2E1 in humans.
TLDR
It can be asserted that CYP2E1 is the major enzyme involved in chlorzoxazone 6-hydroxylation and that the contribution of CYP3A is very minor. Expand
Altered profile of urinary arsenic metabolites in adults with chronic arsenicism A pilot study
TLDR
Relationships between alterations in the profile of urinary arsenic (As) species and the presence of cutaneous signs of arsenicism were studied in Region Lagunera, Mexico to confirm the potential relationship between metabolic alterations and overt signs of As toxicity. Expand
Lymphocyte replicating ability in individuals exposed to arsenic via drinking water.
TLDR
Correlations between LI and MI showed that progression from the initial S-to M-phase is altered in exposed individuals, making the endpoints of cell proliferation variables of interest in population monitoring study design, since they might provide information in health impairment due to exposure, which is important in risk assessment. Expand
Sex-dependent regulation of hepatic cytochrome P-450 by DDT.
TLDR
The preferential induction of CYPs 2B and 3A by DDT in a sex-related manner suggest that CYP regulation could play an important role in endocrine disruption. Expand
CYP1A2 phenotype and genotype in a population from the Carboniferous Region of Coahuila, Mexico.
TLDR
The results suggest that intron I polymorphism and PAH exposure are relevant factors that modulate CYP1A2 enzymatic activity. Expand
Cadmium and mercury toxicity in a human fetal hepatic cell line (WRL-68 cells).
TLDR
WRL-68 cells differentially respond to Cd and Hg making this hepatic fetal human cell line a useful tool in investigating the mechanism of toxicity of these heavy metals. Expand
Altered Urinary Porphyrin Excretion in a Human Po p ulation Chronically Exposed to Arsenic in Mexico
TLDR
The similarities in the urinary porphyrin excretion pattern between As-exposed individuals and Dubin-Johnson syndrome patients suggest that impairments in the excretion of coproporphyr in isomers may also contribute to the pattern observed. Expand
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