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AM 251

Known as: AM-251, AM251 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PiperidinesPyrazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity
Background K2 products are synthetic cannabinoid-laced, marijuana-like drugs of abuse, use of which is often associated with… 
Highly Cited
2010
Highly Cited
2010
Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
BackgroundAdult neurogenesis is a particular example of brain plasticity that is partially modulated by the endocannabinoid… 
Highly Cited
2009
Highly Cited
2009
Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory
Extensive evidence indicates that the basolateral complex of the amygdala (BLA) modulates the consolidation of memories for… 
Highly Cited
2005
Highly Cited
2005
Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and gamma-aminobutyric acid inputs to hypothalamic magnocellular neurons.
Glucocorticoids secreted in response to stress activation of the hypothalamic-pituitary-adrenal axis feed back onto the brain to… 
Highly Cited
2005
Highly Cited
2005
Transient Receptor Potential Vanilloid Subtype 1 Mediates Cell Death of Mesencephalic Dopaminergic Neurons In Vivo and In Vitro
Intranigral injection of the transient receptor potential vanilloid subtype 1 (TRPV1; also known as VR1) agonist capsaicin (CAP… 
Highly Cited
2004
Highly Cited
2004
Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids
Neocortical GABA-containing interneurons form complex functional networks responsible for feedforward and feedback inhibition and… 
Highly Cited
2004
Highly Cited
2004
Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice.
Pharmacological studies suggest a role for CB1 cannabinoid receptors (CB1R) in regulating neurogenesis in the adult brain. To… 
Highly Cited
2003
Highly Cited
2003
Nongenomic Glucocorticoid Inhibition via Endocannabinoid Release in the Hypothalamus: A Fast Feedback Mechanism
Glucocorticoid negative feedback in the brain controls stress, feeding, and neural-immune interactions by regulating the… 
Highly Cited
2003
Highly Cited
2003
Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2 Cannabinoid Receptors
Background Cannabinoid receptor agonists inhibit inflammatory hyperalgesia in animal models. Nonselective cannabinoid receptor… 
Highly Cited
1996
Highly Cited
1996
123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors.
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