Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids

@article{Bacci2004LonglastingSO,
  title={Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids},
  author={A. Bacci and J. Huguenard and D. Prince},
  journal={Nature},
  year={2004},
  volume={431},
  pages={312-316}
}
  • A. Bacci, J. Huguenard, D. Prince
  • Published 2004
  • Biology, Medicine
  • Nature
  • Neocortical GABA-containing interneurons form complex functional networks responsible for feedforward and feedback inhibition and for the generation of cortical oscillations associated with several behavioural functions. We previously reported that fast-spiking (FS), but not low-threshold-spiking (LTS), neocortical interneurons from rats generate a fast and precise self-inhibition mediated by inhibitory autaptic transmission. Here we show that LTS cells possess a different form of self… CONTINUE READING
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