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Neurocircuitry of Addiction
TLDR
The delineation of the neurocircuitry of the evolving stages of the addiction syndrome forms a heuristic basis for the search for the molecular, genetic, and neuropharmacological neuroadaptations that are key to vulnerability for developing and maintaining addiction. Expand
The neural basis of addiction: a pathology of motivation and choice.
TLDR
Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatorgic drive in response to drug-associated stimuli. Expand
Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex.
TLDR
An integrated model of drug addiction that encompasses intoxication, bingeing, withdrawal, and craving is proposed, and results imply that addiction connotes cortically regulated cognitive and emotional processes, which result in the overvaluing of drug reinforcers, the undervalued of alternative rein forcers, and deficits in inhibitory control for drug responses. Expand
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
TLDR
Functional neuroimaging studies conducted in the past decade that have expanded the understanding of the involvement of the PFC in drug addiction are focused on. Expand
Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data
TLDR
This technique provides an alternative method of analysis not requiring blood sampling that gives equivalent results for the two ligands studied, and requires initial studies with blood sampling to determine the average kinetic constant and to test applicability. Expand
Neurocircuitry of Addiction
Correction to: Neuropsychopharmacology Reviews (2010) 35, 217–238; doi:10.1038/npp.2009.110; published online 26 August 2009 In this article, there is an error in Figure 4; a revised Figure 4 isExpand
Brain dopamine and obesity
TLDR
Dopamine modulates motivation and reward circuits and hence dopamine deficiency in obese individuals may perpetuate pathological eating as a means to compensate for decreased activation of these circuits. Expand
Adverse health effects of marijuana use.
TLDR
As marijuana use becomes legal in some states, the dominant public opinion is that marijuana is a harmless source of mood alteration, but enough information is available to cause concern. Expand
Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-11C-Methyl]-(−)-Cocaine PET Studies in Human Subjects
TLDR
It can be shown that, for many systems, linearity is effectively reached some time before this, and this method provides an easy, rapid method for comparison of the reproducibility of repeated measures in a single subject, for longitudinal or drug intervention protocols, or for comparing experimental results between subjects. Expand
Functional connectivity density mapping
  • D. Tomasi, N. Volkow
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 10 May 2010
TLDR
A 103 times faster method to map the distribution of the local functional connectivity density (lFCD) in the human brain is proposed and it is suggested that that brain networks have a “scale-free” organization. Expand
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