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In vivo Effects of Abused ‘Bath Salt’ Constituent 3,4-methylenedioxypyrovalerone (MDPV) in Mice: Drug Discrimination, Thermoregulation, and Locomotor Activity
- W. Fantegrossi, Brenda M Gannon, S. Zimmerman, K. Rice
- Biology, PsychologyNeuropsychopharmacology
- 1 March 2013
Although the interoceptive effects of MDPV are similar to those of MDMA and METH, direct effects on thermoregulatory processes and locomotor activity are likely mediated by different mechanisms than those of ecstasy.
Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity
- L. Brents, E. Reichard, S. Zimmerman, J. Moran, W. Fantegrossi, P. Prather
- Biology, ChemistryPloS one
- 6 July 2011
This study proposes that K2's high adverse effect occurrence is due, at least in part, to distinct JWH-018 metabolite activity at the cannabinoid 1 receptor (CB1R), and suggests that metabolites of most drugs, but not the carboxy metabolite, retain in vitro and in vivo activity at CB1Rs.
Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ(9)-THC: mechanism underlying greater toxicity?
Reinforcing and discriminative stimulus effects of 1-benzylpiperazine and trifluoromethylphenylpiperazine in rhesus monkeys.
3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serotonergic involvement
- W. Fantegrossi, T. Ullrich, K. Rice, J. Woods, G. Winger
- Biology, PsychologyPsychopharmacology
- 19 April 2002
MDMA and its stereoisomers serve as reinforcers in rhesus monkeys and it is suggested that stimulation of 5-HT2A receptors is integral to the reinforcing effects of MDMA.
Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity.
Interaction of 5-HT2A and 5-HT2C Receptors in R(−)-2,5-Dimethoxy-4-iodoamphetamine-Elicited Head Twitch Behavior in Mice
- W. Fantegrossi, J. Simoneau, J. Woods
- Chemistry, BiologyJournal of Pharmacology and Experimental…
- 1 December 2010
Results of these experiments provide strong evidence that DOI-elicited head-twitch behavior is a 5-HT2A agonist-mediated effect, with subsequent inhibition of head- twitch behavior being driven by competing 5- HT2C agonist activity.
Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats
Baths Salts, Spice, and Related Designer Drugs: The Science Behind the Headlines
- M. Baumann, Ernesto Solis, L. Watterson, Julie A. Marusich, W. Fantegrossi, J. Wiley
- BiologyThe Journal of Neuroscience
- 12 November 2014
A brief up-to-date review describing the mechanisms of action and neurobiological effects of synthetic cathinones and cannabinoids is provided.
Behavioral and Neurochemical Consequences of Long-Term Intravenous Self-Administration of MDMA and Its Enantiomers by Rhesus Monkeys
The reinforcing effects of MDMA are selectively attenuated by chronic MDMA self-administration, although this behavioral change appears to occur in the absence of any frank neurochemical correlates of toxicity.