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Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
It is demonstrated that voluntary exercise is sufficient for enhanced neurogenesis in the adult mouse dentate gyrus, in amounts similar to enrichment conditions.
More hippocampal neurons in adult mice living in an enriched environment
It is shown that significantly more new neurons exist in the dentate gyrus of mice exposed to an enriched environment compared with littermates housed in standard cages, and that the enriched mice have a larger hippocampal granule cell layer and 15 per cent moregranule cell neurons in the Dentate Gyrus.
Milestones of neuronal development in the adult hippocampus
Faculty Opinions recommendation of Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans.
- G. Kempermann
- 14 May 2015
Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain
Findings from this study may be useful for elucidating the in vivo role of growth factors in neurogenesis in the adult CNS and may aid development of neuronal replacement strategies after brain damage.
Proliferation and Differentiation of Progenitor Cells Throughout the Intact Adult Rat Spinal Cord
The distribution and incidence of BrdU labeling matched those of the 4 week post injection groups, suggesting that proliferating cells dividein situ rather than migrate from the ependymal zone, and that glial progenitors exist in the outer circumference of the spinal cord that can give rise to both astrocyte and oligodendrocytes.
Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli
It is believed that type 2a, 2b, and 3 cells mirror a marker progression during earliest neuronal development, and this view is supported by the increasing coexpression of the early granule cell‐specific marker Prox‐1.
Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging.
Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice
The discovery of BrdU-labeled neurons suggests that new neurons are recruited early from the pool of proliferating progenitor cells and lead to a lasting effect of adult neurogenesis.
Genetic influence on neurogenesis in the dentate gyrus of adult mice.
- G. Kempermann, H. Kuhn, F. Gage
- BiologyProceedings of the National Academy of Sciences…
- 16 September 1997
The results show that different aspects of adult hippocampal neurogenesis are differentially influenced by the genetic background.