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In vivo Effects of Abused ‘Bath Salt’ Constituent 3,4-methylenedioxypyrovalerone (MDPV) in Mice: Drug Discrimination, Thermoregulation, and Locomotor Activity
- W. Fantegrossi, Brenda M Gannon, S. Zimmerman, K. Rice
- Biology, PsychologyNeuropsychopharmacology
- 1 March 2013
Although the interoceptive effects of MDPV are similar to those of MDMA and METH, direct effects on thermoregulatory processes and locomotor activity are likely mediated by different mechanisms than those of ecstasy.
Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity
- L. Brents, E. Reichard, S. Zimmerman, J. Moran, W. Fantegrossi, P. Prather
- Biology, ChemistryPloS one
- 6 July 2011
This study proposes that K2's high adverse effect occurrence is due, at least in part, to distinct JWH-018 metabolite activity at the cannabinoid 1 receptor (CB1R), and suggests that metabolites of most drugs, but not the carboxy metabolite, retain in vitro and in vivo activity at CB1Rs.
Interaction of 5-HT2A and 5-HT2C Receptors in R(−)-2,5-Dimethoxy-4-iodoamphetamine-Elicited Head Twitch Behavior in Mice
- W. Fantegrossi, J. Simoneau, J. Woods
- Chemistry, BiologyJournal of Pharmacology and Experimental…
- 1 December 2010
Results of these experiments provide strong evidence that DOI-elicited head-twitch behavior is a 5-HT2A agonist-mediated effect, with subsequent inhibition of head- twitch behavior being driven by competing 5- HT2C agonist activity.
AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies
Differential Drug–Drug Interactions of the Synthetic Cannabinoids JWH-018 and JWH-073: Implications for Drug Abuse Liability and Pain Therapy
- L. Brents, S. Zimmerman, A. Saffell, P. Prather, W. Fantegrossi
- BiologyThe Journal of Pharmacology and Experimental…
- 1 September 2013
Data indicate that drug–drug interactions between JWH-018 andJWH-073 are effect- and ratio-dependent and may increase the relative potency of marijuana substitutes for subjective Δ9-THC–like effects.
Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation
This work describes the critical role of SC65 (Synaptonemal Complex 65, P3H4), a leprecan-family member, as part of an endoplasmic reticulum (ER) complex with prolyl 3-hydroxylase 3 controlling lysyl-Hydroxyl enzyme activity during collagen synthesis.
The Osteocyte Transcriptome Is Extensively Dysregulated in Mouse Models of Osteogenesis Imperfecta
It is suggested that the osteocyte transcriptome is broadly dysregulated in OI with potential long‐term consequences at the cellular level, which deserve further investigations.
Loss of RANKL in osteocytes dramatically increases cancellous bone mass in the osteogenesis imperfecta mouse (oim)
Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.