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Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex.
TLDR
Slices of sensorimotor and anterior cingulate cortex from guinea pigs were maintained in vitro and bathed in a normal physiological medium, observing three distinct neuronal classes of electrophysiological behavior; these were regular spiking, bursting, and fast spiking. Expand
Electrophysiological properties of neocortical neurons in vitro.
TLDR
The array of passive and active membrane behavior observed in the slice suggests that cortical neurons may be differentiated by specific functional properties as well as by their extensive morphological diversity. Expand
A novel T-type current underlies prolonged Ca(2+)-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus
TLDR
It is demonstrated that subtypes of transient Ca2+ current are present in two different classes of thalamic neurons, including steady-state inactivation and sensitivities to blockade by divalent cations, amiloride, and antiepileptic drugs. Expand
Intrathalamic rhythmicity studied in vitro: nominal T-current modulation causes robust antioscillatory effects
TLDR
It is concluded that interactions between the intrinsic properties of thalamic neurons and intrathalamic circuitry lead to generation of slow oscillations and a similar mechanism may underlie the pathophysiological 3 Hz spike and wave EEG activity that characterizes GA. Expand
Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low‐threshold current.
TLDR
Calcium currents were recorded with whole‐cell voltage‐clamp procedures in relay neurones of the rat thalamus which had been acutely isolated by an enzymatic dissociation procedure and could be modelled in a manner analogous to that employed for the fast Na+ current underlying action potential generation, using the m3h format. Expand
Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro.
TLDR
It is concluded that cholinergic inhibition of pyramidal neurones is mediated through a rapid muscarinic excitation of non‐pyramidal cells, resulting in the release of GABA. Expand
Cholinergic switching within neocortical inhibitory networks.
TLDR
Cortical cholinergic activation may reduce some forms of intralaminar inhibition, promote intracolumnar inhibited inhibition, and change the direction of information flow within cortical circuits. Expand
Spontaneous GABAA receptor-mediated inhibitory currents in adult rat somatosensory cortex.
TLDR
There is ongoing spontaneous release of GABA in neocortical slices that gives rise to high-frequency impulse-related and non-impulse-related postsynaptic inhibitory currents, and the distribution of inhibitory synapses throughout the cortex is relatively uniform. Expand
Clonazepam suppresses GABAB-mediated inhibition in thalamic relay neurons through effects in nucleus reticularis.
TLDR
It is demonstrated that nRt is a site of GABAA-mediated postsynaptic inhibition that affects inhibitory output onto relay neurons and has an important role in controlling thalamic excitability and in the anti-absence actions of CZP. Expand
Burst generating and regular spiking layer 5 pyramidal neurons of rat neocortex have different morphological features
TLDR
Intracellular recordings were obtained from pyramidal neurons in layer 5 of rat somatosensory and visual cortical slices maintained in vitro to study the responses of bursting and regular spiking cells to depolarizing afterpotentials. Expand
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