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alpha 1-Antitrypsin

Known as: Serine (or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1, Trypsin Inhibitor, alpha 1-Antitrypsin, alpha-1 antitrypsin 
Alpha-1-antitrypsin (418 aa, ~47 kDa) is encoded by the human SERPINA1 gene. This protein plays a role in regulation of proteolysis.
National Institutes of Health

Related topics

Related topics

32 relations
Alpha 1 antitrypsin Ag:PrThr:Pt:Tiss:Ord:Immune stainAlpha 1 antitrypsin:MCnc:Pt:Stool:QnAlpha 1 antitrypsin:MCnt:24H:Stool:QnAlpha 1 antitrypsin:MCnt:72H:Stool:Qn

Narrower (9)

C105Y peptideGlassiaProlastinUBE peptide, mouse

Broader (3)

Pancreatic ElastaseSerine Proteinase InhibitorsTrypsin Inhibitors

Papers overview

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Highly Cited
2015
Highly Cited
2015
Neonatal lung neutrophils and elastase/proteinase inhibitor imbalance.
Serial bronchoalveolar lavage (BAL) was performed prospectively on 10 normal control subjects, 20 Respiratory Distress Syndrome… 
Highly Cited
1994
Highly Cited
1994
Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation.
A detailed evaluation of the antioxidant and pro-oxidant properties of lipoic acid (LA) and dihydrolipoic acid (DHLA) was… 
Highly Cited
1992
Highly Cited
1992
Inactivation of alpha 1-proteinase inhibitor by peroxynitrite.
We here report the reactions of peroxynitrite (O=NOO-) with alpha 1-proteinase inhibitor (alpha 1PI) and with a synthetic… 
Highly Cited
1992
Highly Cited
1992
Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes.
The liver represents an excellent organ for gene therapy since many genetic disorders result from the deficiency of liver… 
Highly Cited
1989
Highly Cited
1989
Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes
Transthyretin (TTR) and alpha 1-antitrypsin (alpha 1-AT) are expressed at high levels in the liver and also in at least one other… 
Highly Cited
1986
Highly Cited
1986
Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.
The neutrophil has been implicated as an important mediator of vascular injury, especially after endotoxemia. This study examines… 
Highly Cited
1986
Highly Cited
1986
Expression of the alpha-1-antitrypsin gene in mononuclear phagocytes of normal and alpha-1-antitrypsin-deficient individuals.
To evaluate the contribution of mononuclear phagocytes, and particularly alveolar macrophages, to alpha-1-antitrypsin (alpha 1AT… 
Highly Cited
1983
Highly Cited
1983
Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmonary dysplasia.
Pulmonary effluent samples were obtained from 26 preterm or term infants throughout the period of endotracheal intubation… 
Highly Cited
1980
Highly Cited
1980
Potential mediator of inflammation. Phagocyte-derived oxidants suppress the elastase-inhibitory capacity of alpha 1-proteinase inhibitor in vitro.
Human polymorphonuclear leukocytes, monocytes, or pulmonary alveolar macrophages, stimulated in vitro by phorbol myristate… 
Highly Cited
1978
Highly Cited
1978
Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor.
An unadecapeptide, obtained by papain digestion of denatured human alpha-1-proteinase inhibitor (alpha-1-PI), has been isolated… 
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