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Pancreatic Elastase

Known as: Elastase, Elastase.pancreatic, pancreatopeptidase E 
A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific… 
National Institutes of Health

Related topics

Related topics

22 relations
CELA1 geneCELA3A geneCELA3B geneElastase.pancreatic 2:CCnc:Pt:Ser:Qn

Narrower (8)

Elastase ILeukocyte ElastaneMedullasinMyxococcus xanthus alkaline protease 1

Broader (1)

Elastases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension
Primary pulmonary hypertension is a progressive and often fatal disorder in humans that results from an increase in pulmonary… 
Highly Cited
2000
Highly Cited
2000
Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.
Highly Cited
1999
Highly Cited
1999
Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response.
Highly Cited
1992
Highly Cited
1992
Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.
The respiratory manifestations of cystic fibrosis (CF) are characterized by neutrophil-dominated airway inflammation. Since a… 
Highly Cited
1992
Highly Cited
1992
Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties.
Highly Cited
1990
Highly Cited
1990
Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties.
Human rheumatoid synovial cells in culture secrete at least three related metalloproteinases that digest extracellular matrix… 
Review
1989
Review
1989
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
The serine protease family of enzymes is one of the most widely studied group of enzymes, as evidenced by the fact that more… 
Highly Cited
1986
Highly Cited
1986
Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.
The neutrophil has been implicated as an important mediator of vascular injury, especially after endotoxemia. This study examines… 
Highly Cited
1983
Highly Cited
1983
Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmonary dysplasia.
Pulmonary effluent samples were obtained from 26 preterm or term infants throughout the period of endotracheal intubation… 
Highly Cited
1979
Highly Cited
1979
Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.
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