Skip to search formSkip to main contentSkip to account menu

Leukocyte Elastane

Known as: Granulocyte-Derived Elastase, Human Leukocyte Elastase, Elastase, PMN 
An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with… 
National Institutes of Health

Related topics

Related topics

19 relations
ELANE geneElastase.leukocytary:CCnc:Pt:Plas:QnEnzyme GeneHydrolysis

Broader (2)

ElastasesPancreatic Elastase

Narrower (2)

Medullasinalpha 1-antitrypsin-leukocyte elastase complex

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1996
Highly Cited
1996
Neutrophil rolling altered by inhibition of L-selectin shedding in vitro
THE L-selectin adhesion molecule is involved in guiding leuko-cytes to sites of inflammation1. L-selectin is cleaved by an… 
Highly Cited
1992
Highly Cited
1992
Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.
The respiratory manifestations of cystic fibrosis (CF) are characterized by neutrophil-dominated airway inflammation. Since a… 
Review
1992
Review
1992
Phenobarbital induction of cytochrome P-450 gene expression.
RESEARCH PAPERS' Proteins Generation of forms of fragment E with differing thrombin-binding properties during digestion of… 
Highly Cited
1992
Highly Cited
1992
Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties.
Highly Cited
1991
Highly Cited
1991
Lectin-like cell adhesion molecule 1 mediates leukocyte rolling in mesenteric venules in vivo.
During the inflammatory response, granulocytes and other leukocytes adhere to and emigrate from small venules. Before firm… 
Highly Cited
1991
Highly Cited
1991
Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: Myeloperoxidase activity assay and histologic verification
Two different techniques were utilized to identify the infiltration of polymorphonuclear leukocytes (PMN) into cerebral tissue… 
Highly Cited
1991
Highly Cited
1991
Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium.
It has been suggested that proteinase enzymes could play an important role in the pathogenesis of chronic bronchial infections… 
Highly Cited
1986
Highly Cited
1986
Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates.
In vitro and in vivo studies have suggested that human complement component C5a plays a key role in neutrophil injury in the… 
Highly Cited
1979
Highly Cited
1979
Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.
Highly Cited
1968
Highly Cited
1968
MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES
The present study demonstrates that a granule fraction derived from human polymorphonuclear leukocytes possesses elastinolytic… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)