Leukocyte Elastane

Known as: Granulocyte-Derived Elastase, Human Leukocyte Elastase, Elastase, PMN 
An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Neutrophils play an important role in innate immunity by defending the host organism against invading microorganisms… (More)
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Highly Cited
2010
Highly Cited
2010
Neutrophils release decondensed chromatin termed neutrophil extracellular traps (NETs) to trap and kill pathogens extracellularly… (More)
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Highly Cited
2004
Highly Cited
2004
Elastic fibers are components of the extracellular matrix and confer resilience. Once laid down, they are thought to remain… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Polymorphonuclear neutrophils (PMNs) have gained attention as critical mediators of acute coronary syndromes (ACS… (More)
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Highly Cited
2002
Highly Cited
2002
Increased leukocyte elastase activity in mice lacking secretory leukocyte protease inhibitor (SLPI) leads to impaired wound… (More)
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Review
2000
Review
2000
Phenotypic modulation of endothelium to a dysfunctional state contributes to the pathogenesis of cardiovascular diseases such as… (More)
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Highly Cited
1997
Highly Cited
1997
Leukocyte trafficking at the endothelium requires both cellular adhesion molecules and chemotactic factors. Fractalkine, a novel… (More)
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Highly Cited
1996
Highly Cited
1996
alpha(1,3)Fucosylated oligosaccharides represent components of leukocyte counterreceptors for E- and P-selectins and of L… (More)
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Highly Cited
1993
Highly Cited
1993
Accumulation of monocyte-derived foam cells in focal areas of the arterial intima is a key step in early atherogenesis. We… (More)
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Highly Cited
1982
Highly Cited
1982
1. L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) at a concentration of 0.5 mM had no effect on the serine… (More)
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