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Acute otitis media: management and surveillance in an era of pneumococcal resistance--a report from the Drug-resistant Streptococcus pneumoniae Therapeutic Working Group.
Recommendations to improve surveillance include establishing criteria for setting susceptibility breakpoints for clinically appropriate antimicrobials to ensure relevance for treating AOM, testing middle ear fluid or nasal swab isolates in addition to sterile site isolates and testing of drugs that are useful in treating Aom.
Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials.
Treatment with beta-lactamase-stable agents does not increase resolution of acute symptoms or middle ear effusion; initial therapy should be guided by considerations of safety, tolerability, and affordability, and not by the theoretical advantage of an extended antibacterial spectrum.
Epidemiology of Otitis Media Onset by Six Months of Age
- K. Daly, Judith E. Brown, B. Lindgren, Maria Meland, C. Le, G. Giebink
- 1 June 1999
Among prenatal exposures, only high prenatal dietary vitamin C intake was significantly inversely related to early AOM with univariate but not multivariate analysis, but environmental and innate factors play an important role inEarly AOM onset.
Impact of Surgical Treatment on Paranasal Fungal Infections in Bone Marrow Transplant Patients
- C. Kennedy, G. Adams, J. Neglia, G. Giebink
- MedicineOtolaryngology--head and neck surgery : official…
- 1 June 1997
Between January 1983 and June 1993, 29 bone marrow transplant recipients with documented invasive fungal infections of the sinuses and paranasal tissues required surgical intervention, and prognosis was poor when cranial and orbital involvement and/or bony erosion occurred.
Haemophilus influenzae type B conjugate vaccine
High Frequency Hearing Loss Associated with Otitis Media
- L. Hunter, R. Margolis, J. R. Rykken, C. Le, K. Daly, G. Giebink
- MedicineEar and hearing
- 1 February 1996
High frequency hearing loss was associated with OM after middleEar disease resolved and after middle ear dysfunction was excluded, suggesting that the effects of OM on hearing thresholds may be progressive.
Amoxicillin middle ear fluid penetration and pharmacokinetics in children with acute otitis media.
- D. Canafax, Z. Yuan, T. Chonmaitree, K. Deka, H. Russlie, G. Giebink
- MedicineThe Pediatric infectious disease journal
- 1 February 1998
MEF amoxicillin penetration tended to be lower in children with viral infection, which is inadequate to effectively eradicate resistant Streptococcus pneumoniae, particularly during viral coinfection.
Influenza A virus-induced polymorphonuclear leukocyte dysfunction in the pathogenesis of experimental pneumococcal otitis media
Animals that had unilateral tympanostomy tubes placed before inoculation of influenza with pneumococcus showed no difference in the occurrence of pneumococcal otitis media in ventilated and nonventilated ears, suggesting that polymorphonuclear leukocyte dysfunction contributes more to the pathogenesis of pneumonia than does negative middle ear pressure in this animal model.
The pathogenesis of pneumococcal otitis media in chinchillas and the efficacy of vaccination in prophylaxis.
- G. Giebink
- MedicineReviews of infectious diseases
- 1 March 1981
Systemically administered pneumococcal capsular polysaccharide vaccine was effective for prevention of type-specific otitis media in chinchillas when vaccinated animals were challenged by intranasal inoculation with pneumococci followed by deflation of the middle ear.
Disseminated infection with Fusarium in recipients of bone marrow transplants.
It appears that recovery of phagocytic mechanisms (the primary immunologic defenses against Fusarium) in the form of rising neutrophil counts is mandatory for clinical resolution, as evidenced by the high incidence of recurrence among patients with subsequent neutropenic episodes.