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ELANE gene

Known as: MEDULLASIN, HLE, elastase, neutrophil expressed 
This gene plays a role in innate host defense.
National Institutes of Health

Related topics

Related topics

7 relations
CELA1 geneHydrolysisLeukocyte ElastaneMedullasin

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ELANE wt Allele

Papers overview

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Review
2014
Review
2014
Cellular stress pathways in pediatric bone marrow failure syndromes: many roads lead to neutropenia
The inherited bone marrow failure syndromes, like severe congenital neutropenia (SCN) and Shwachman–Diamond syndrome (SDS… 
2000
2000
Detection of 4-hydroxy-2-nonenol adducts following lipid peroxidation from ozone exposure.
2000
2000
A novel endoproteolytic processing activity in mitochondria of erythroid cells and the role in heme synthesis.
The erythroid isoform of aminolevulinate synthase (eALAS) protein is a major control point in erythroid heme synthesis and… 
1997
1997
Immunohistochemical study of cathepsin G and medullasin in inflamed gingival tissues from periodontal patients.
Cathepsin G and medullasin are 2 major serine proteinases associated with the granular fraction of polymorphonuclear leukocytes… 
1993
1993
Possible functions of human neutrophil serine proteinases, medullasin and cathepsin G, in periodontal tissue breakdown.
1993
1993
Both medullasin and human leukocyte elastase are essentially devoid of elastinolytic activity.
Elastinolytic activity of medullasin was investigated precisely and compared with that of human leukocyte elastase, because the… 
1990
1990
Granulocyte medullasin levels in gingival crevicular fluid from chronic adult periodontitis patients and experimental gingivitis subjects.
The concentration of medullasin, an elastase-like serine proteinase, in gingival crevicular fluid (GCF) from chronic adult… 
1988
1988
Molecular cloning of human neutrophil elastase.
The human U937 cell line, a promonocyte-like leukemic line, has been shown to synthesize neutrophil elastase (Senior, R. M. et al… 
1987
1987
Nucleotide sequence of human bone marrow serine protease (medullasin) gene.
The complete genomic sequence of human bone marrow serine protease (medullasin) (1) was determined from a clone of a 6Kb EcoRI… 
1987
1987
Molecular cloning of complementary DNA for human medullasin: an inflammatory serine protease in bone marrow cells.
Medullasin, an inflammatory serine protease in bone marrow cells, modifies the functions of natural killer cells, monocytes, and… 
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