ELANE gene

Known as: MEDULLASIN, HLE, elastase, neutrophil expressed 
This gene plays a role in innate host defense.
National Institutes of Health

Papers overview

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Review
2013
Review
2013
The 2 main forms of hereditary neutropenia are cyclic (CN) and severe congenital (SCN) neutropenia. CN is an autosomal dominant… (More)
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Review
2010
Review
2010
Biological electrophiles result from oxidative metabolism of exogenous compounds or endogenous cellular constituents, and they… (More)
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Highly Cited
2009
Highly Cited
2009
Severe congenital neutropenia (SCN) is a genetically heterogeneous syndrome associated with mutations of ELANE (ELA2), HAX1, GFI1… (More)
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Highly Cited
2009
Highly Cited
2009
Early Alzheimer's disease (EAD) is the intermediary stage between mild cognitive impairment (MCI) and late-stage Alzheimer's… (More)
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2009
2009
4-Hydroxynonenal (HNE) is one of several lipid oxidation products that may have an impact on human pathophysiology. It is an… (More)
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2007
2007
The modification of proteins by the cytotoxic, reactive aldehyde 4-hydroxynonenal (HNE) is known to alter protein function and… (More)
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Highly Cited
2005
Highly Cited
2005
Heme oxygenase-1 (HO-1) is a key cytoprotective enzyme and an established marker of oxidative stress. Increased HO-1 expression… (More)
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Highly Cited
2004
Highly Cited
2004
4-hydroxynonenal (HNE), a highly reactive lipid peroxidation product, may adversely modify proteins. Accumulation of HNE-modified… (More)
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Highly Cited
1998
Highly Cited
1998
Neutrophil elastase (NE) is a potent serine proteinase1,2 whose expression is limited to a narrow window during myeloid… (More)
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