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LEKTI, a Novel 15-Domain Type of Human Serine Proteinase Inhibitor*
It is assumed that LEKTI may play a role in anti-inflammatory and/or antimicrobial protection of mucous epithelia, as all of the 13 HF6478- and HF7665-related domains share partial homology to the typical Kazal-type domain but lack one of the three conserved disulfide bonds.
Anti-neutrophil elastase defense of the normal human respiratory epithelial surface provided by the secretory leukoprotease inhibitor.
SLPI is present in large amounts in respiratory ELF, but since the majority of the SLPI is inactive, it likely does not play a significant role in protecting the normal respiratory epithelium, except perhaps in the upper airways where the levels of SLPI are the highest.
Inflammatory mediators, infection, sepsis, and multiple organ failure after severe trauma.
The data indicate that infection might not play a crucial role in the pathogenesis of posttraumatic OF in a substantial portion of patients with trauma, and only polymorphonuclear leukocyte-elastase showed a difference between patients with and without infection or sepsis.
Ionomycin-activated Calpain Triggers Apoptosis
It is concluded that ionomycin-induced calpain activation promotes decrease of Bcl-2 proteins thereby triggering the intrinsic apoptotic pathway.
Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs.
The present knowledge of the subject in various disciplines is summarized, it provides the active scientist with basic data for his experimental work; and above all it points the way to future directions of aprotinin research.
Human β-tryptase is a ring-like tetramer with active sites facing a central pore
Human tryptase, a mast-cell-specific serine proteinase that may be involved in causing asthma and other allergic and inflammatory disorders, is unique in two respects: it is enzymatically active only
Primary structure of a Kunitz-type trypsin inhibitor from Enterolobium contortisiliquum seeds.
ECTI inhibits trypsin and chymotrypsin in the stoichiometric ratio of 1:1 and also Factor XIIa, plasma kallikrein and plasmin, but not thrombin and Factor Xa.
Amino-acid sequence of a coelenterate toxin: toxin II from Anemonia sulcata.
Toxin II from Anemonia sulcata, the main component of the sea anemone venom, consists of 47 amino acid residues which are interconnected by three disulfide bridges and might constitute a new class of polypeptide toxins.
Structure of the elastase-cathepsin G inhibitor of the leech Hirudo medicinalis.
The leech Hirudo medicinalis contains three different groups of proteinase inhibitor proteins, the thrombin-specific hirudin, the bdellins directed against trypsin, plasmin and acrosin, and the