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Alpha-macroglobulins: structure, shape, and mechanism of proteinase complex formation.
- L. Sottrup-jensen
- BiologyThe Journal of biological chemistry
- 15 July 1989
The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A.
- J. Lawrence, C. Oxvig, C. Conover
- Biology, MedicineProceedings of the National Academy of Sciences…
- 16 March 1999
An IGF-dependent IGFBP-4-specific protease is identified and at the same time assigned a function to pregnancy-associated plasma protein-A (PAPP-A), a protein of unknown function found in high concentrations in the maternal circulation during pregnancy.
Pregnancy-associated Plasma Protein-A2 (PAPP-A2), a Novel Insulin-like Growth Factor-binding Protein-5 Proteinase*
- M. Overgaard, H. Boldt, L. Laursen, L. Sottrup-jensen, C. Conover, C. Oxvig
- BiologyThe Journal of Biological Chemistry
- 15 June 2001
A novel metalloproteinase with similarity to pregnancy-associated plasma protein-A (PAPP-A), which is a likely candidate IGFBP-5 proteinase in many tissues and conditioned media where IGF BP-5 proteolysis has been reported.
Molecular Characterization of a Novel Human Hybrid-type Receptor That Binds the α2-Macroglobulin Receptor-associated Protein*
The domain structure suggests that sorLA-1 is an endocytic receptor possibly implicated in the uptake of lipoproteins and of proteases, and may be classified as a hybrid receptor.
Pregnancy‐associated plasma protein‐A (PAPP‐A) cleaves insulin‐like growth factor binding protein (IGFBP)‐5 independent of IGF: implications for the mechanism of IGFBP‐4 proteolysis by PAPP‐A
The crayfish plasma clotting protein: a vitellogenin-related protein responsible for clot formation in crustacean blood.
- M. Hall, R. Wang, R. van Antwerpen, L. Sottrup-jensen, K. Söderhäll
- BiologyProceedings of the National Academy of Sciences…
- 2 March 1999
The cloning of the subunit of this clotting protein from a crayfish hepatopancreas cDNA library is reported, revealing that the clottingprotein is homologous to vitellogenins, which are proteins found invitellogenic females of egg-laying animals.
Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
- N. S. Laursen, N. Gordon, G. Andersen
- BiologyProceedings of the National Academy of Sciences
- 23 February 2010
The results provide a conceptual and structural basis for the development of a highly specific complement inhibitor preventing only the formation of the lytic membrane attack complex without affecting the important signaling functions of C5a.
Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin.
- H. Boldt, M. Overgaard, L. Laursen, K. Weyer, L. Sottrup-jensen, C. Oxvig
- BiologyThe Biochemical journal
- 1 September 2001
The hypothesis that PAPP-A belongs to the metzincin superfamily of metalloproteinases, all containing the elongated zinc-binding motif HEXXHXXGXXH, is supported by secondary-structure prediction, and the ability of a 55-residue deletion mutant to express and retain antigenecity is supported.
Partial primary structure of bovine plasma fibronectin: three types of internal homology.
- T. E. Petersen, H. Thøgersen, S. Magnusson
- Biology, ChemistryProceedings of the National Academy of Sciences…
Three types of internal homology were identified, showing that a number of partial gene duplications (multiplications) have occurred during the evolution of this protein.
The crystal structure of human α2-macroglobulin reveals a unique molecular cage.
I'm your Venus: the crystal structure of the human methylamine-induced form of α(2)-macroglobulin (α(2)M) shows its large central cavity can accommodate two medium-sized proteinases. Twelve major…