Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmonary dysplasia.

@article{Merritt1983ElastaseAA,
  title={Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmonary dysplasia.},
  author={T. Merritt and C. Cochrane and K. Holcomb and B. Bohl and M. Hallman and D. Strayer and D. Edwards and L. Gluck},
  journal={The Journal of clinical investigation},
  year={1983},
  volume={72 2},
  pages={
          656-66
        }
}
Pulmonary effluent samples were obtained from 26 preterm or term infants throughout the period of endotracheal intubation. Infants with respiratory distress syndrome, infants with this disorder developing bronchopulmonary dysplasia, and intubated infants without lung disease were compared daily in terms of lung effluent cellularity, albumin, elastase activity, alpha 1-proteinase content and activity, and elastase inhibitory capacity. The elastase activity was determined to be neutrophilic in… Expand
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