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Long-Term Response to Calcium Channel Blockers in Idiopathic Pulmonary Arterial Hypertension
TLDR
Long-term CCB responders represent <10% of IPAH patients evaluated in a pulmonary vascular referral center, and during acute vasodilator testing, these patients showed significantly lower levels of both mean PAP and PVR, which reached near-normal values. Expand
Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival.
TLDR
It is suggested that lung transplantation should be considered in a subset of patients who remain in NYHA functional class III or IV or in those who cannot achieve a significant hemodynamic improvement after three months of epoprostenol therapy, or both. Expand
Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension.
TLDR
PDGF may play an important role in human PAH and novel therapeutic strategies targeting the PDGF pathway should be tested in clinical trials. Expand
Prognostic factors for survival in human immunodeficiency virus-associated pulmonary arterial hypertension.
TLDR
Patients with severe human immunodeficiency virus-associated PAH should be considered for long-term epoprostenol infusion in association with CART, according to multivariate analysis and prognostic factors. Expand
Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension
TLDR
Using the chronic-hypoxic-mouse model of pulmonary hypertension, it is found that the hypoxia-dependent increase in pulmonary blood pressure and lung remodeling are associated with an increase in vascular proliferation, elastase activity and transforming growth factor-β levels, and that these parameters are potentiated by dexfenfluramine treatment. Expand
New formula for predicting mean pulmonary artery pressure using systolic pulmonary artery pressure.
TLDR
In resting humans, MPAP can be accurately predicted from SPAP over a wide pressure range, and the new formula may help to refine the threshold pressure values used in the diagnosis of PH. Expand
5‐hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension
TLDR
Pharmacological evidence is reviewed that suggests changes in 5-HT availability,5-HT-induced vasoconstriction, 5-ht-induced mitogenesis and 5- HT transporter activity are associated with the development of PAH. Expand
Severe pulmonary hypertension in histiocytosis X.
TLDR
Results indicate that pulmonary hypertension in pulmonary histiocytosis X might be related to an intrinsic pulmonary vascular disease, in which the pulmonary circulation is involved independent of small airway and lung parenchyma injury. Expand
Pulmonary vascular disorders in portal hypertension.
TLDR
The severity of hepatopulmonary syndrome seems to parallel the severity of liver failure, whereas no simple relationship has been identified between hepatic impairment and the severity in portopul pulmonary hypertension. Expand
Increased plasma serotonin in primary pulmonary hypertension.
TLDR
The persistent decrease in platelet storage of serotonin after heart-lung transplantation suggests that this platelet abnormality is not secondary to PPH, and normal handling of serotonin by platelets leading to an increase in plasma serotonin occurs in PPH. Expand
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