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Diagnosis of the respiratory distress syndrome by amniocentesis.
Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmonary dysplasia.
Pulmonary effluent neutrophils, macrophages, and elastase activity were increased by day 3 of life in infants with respiratory distress syndrome eventually developing bronchopulmonary dysplasia, and Elastase inhibitory capacity and alpha 1-proteinase inhibitor activity were reduced in infants developing chronic lung disease. Expand
Evidence of lung surfactant abnormality in respiratory failure. Study of bronchoalveolar lavage phospholipids, surface activity, phospholipase activity, and plasma myoinositol.
In respiratory failure, the lipid-protein complexes from lung lavage were not surface active, whereas that from healthy controls had surface properties similar to lung surfactant, and phospholipids from patients with respiratory failure were similar to those from respiratory distress syndrome in the newborn. Expand
Lecithin-sphingomyelin ratios in amniotic fluid in normal and abnormal pregnancy.
It is suggested that an association exists between general major organ system maturation of the fetus—“functional maturity”-and the L/S ratio, independent of gestational age or birth weight. Expand
Exogenous human surfactant for treatment of severe respiratory distress syndrome: a randomized prospective clinical trial.
The efficacy of treatment with human surfactant in preterm infants with severe respiratory distress syndrome is confirmed and pneumothorax, pulmonary interstitial emphysema, and need for FiO2 greater than or equal to 0.3 for greater than 30 days was significantly less in the surfactan group. Expand
Phosphatidylinositol and phosphatidylglycerol in amniotic fluid: indices of lung maturity.
Analysis of PI and PG in amniotic fluid as markers of surfactant seems to be of value as an additional index of prenatal evaluation of lung maturity and may be particularly useful when the specimen is contaminated with blood. Expand
The interpretation and significance of the lecithin-sphingomyelin ratio in amniotic fluid.
General principles of acetone precipitation are presented as a guide in clinical interpretation of the L/S ratio and evidence is presented that there is continuity between the fetal lungs and amniotic fluid. Expand
The lung profile. I. Normal pregnancy.
The lung profile run by two-dimensional thin-layer chromatography is described, including the L/S ratio and the percentages of disaturated acetone precipitated lecithin, PI, and PG. Results show thatExpand
Effect of Surfactant Substitution on Lung Effluent Phospholipids in Respiratory Distress Syndrome: Evaluation of Surfactant Phospholipid Turnover, Pool Size, and the Relationship to Severity of
Lung effluent phospholipids were studied in 29 small preterm infants with severe RDS and the saturated phosphatidylcholine/ sphingomyelin ratio increased during the surfactant-induced remission of respiratory failure, decreased during the relapse of respiratory Failure, and increased again during the recovery. Expand