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Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide.
Peroxynitrite [oxoperoxonitrate(1-), ONOO-] may be formed in vivo from superoxide and nitric oxide. The anion is stable, but the acid (pKa = 6.8) decays to nitrate with a rate of 1.3 s-1 at 25Expand
Effect of olive oil minor components on oxidative stress and arachidonic acid mobilization and metabolism by macrophages RAW 264.7.
  • J. J. Moreno
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 1 November 2003
The effects of squalene, beta-sitosterol, and tyrosol, which are representative of the hydrocarbons, sterols, and polyphenols of olive oil, respectively, on superoxide anion (O2(-)), hydrogen peroxide (H2O2), and nitric oxide (*NO) levels were determined. Expand
Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production.
Results show that resveratrol exerted a strong inhibitory effect on superoxide radical (O2-) and hydrogen peroxide (H2O2) produced by macrophages stimulated by lipopolysaccharides (LPS) or phorbol esters (PMA). Expand
beta-Sitosterol modulates antioxidant enzyme response in RAW 264.7 macrophages.
The results show that beta-sitosterol reverts the impairment of the glutathione/oxidized glutATHione ratio induced by phorbol esters in RAW 264.7 macrophage cultures, and demonstrate that the effects of beta- sitosterol on antioxidant enzymes depend on the estrogen/phosphatidylinositol 3-kinase pathway. Expand
New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.
The present review discusses current observations regarding the role of HETEs in apoptosis, angiogenesis, the proliferation of cancer cells and metastasis, which constitute a potential area for successful therapeutic intervention. Expand
β-Sitosterol modulates antioxidant enzyme response in RAW 264.7 macrophages
Uncontrolled production of reactive oxygen species contributes to the pathogenesis of diseases such as cancer and cardiovascular disorders. Olive oil exerts remarkable preventive effects on theExpand
PGE2 promotes Ca2+-mediated epithelial barrier disruption through EP1 and EP4 receptors in Caco-2 cell monolayers.
The results indicate that EP(1) and EP(4) but not EP(2) andEP(3) might be involved in PP regulation, as mucosal levels of this eicosanoid are also increased in these inflammatory processes. Expand
Effects of an anti-inflammatory peptide (antiflammin 2) on cell influx, eicosanoid biosynthesis and oedema formation by arachidonic acid and tetradecanoyl phorbol dermal application.
The results indicate that the anti-inflammatory effect of antiflammins can be attributed to AA mobilization and/or 5 lipoxygenase inhibition but can be dissociated from an effect on arachidonic acid metabolism by the cyclooxygen enzyme pathway. Expand
Polyphenols, food and pharma. Current knowledge and directions for future research.
The most relevant current knowledge is presented and directions for future research in these fields are proposed, from the culinary world to the clinical setting, and how much scientific truth lies in Hippocrates' famous quote: "Let your food be your medicine". Expand
Role of eicosanoids on intestinal epithelial homeostasis.
This overview focuses on the physiological and physiopathological roles of eicosanoids in cell growth/cell differentiation/apoptosis and in the paracellular permeability of the intestinal epithelium. Expand