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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.
TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).
Signalling: STATs: transcriptional control and biological impact
TLDR
The signal transducer and activator of transcription proteins are among the most well studied of the latent cytoplasmic signal-dependent transcription-factor pathways, and their dysregulation contributes to human disease.
STATs and gene regulation.
TLDR
The discovery of a STAT in Drosophila, and most recently in Dictyostelium discoideum, implies an ancient evolutionary origin for this dual-function set of proteins.
Stat3 as an Oncogene
Stat3 as an Oncogene
Transcriptional responses to polypeptide ligands: the JAK-STAT pathway.
TLDR
This review will examine how two receptor associated tyrosine kinases from the JAK family mediate the transduction of signal directly from receptor to nucleus.
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