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Mortality in relation to smoking : 50 years’observations on male British doctors, R. Doll, R. Peto, J. Boreham, I. Sutherland, in: BMJ, 328. (2004), 1519
Nicotine inhaler and nicotine patch as a combination therapy for smoking cessation: a randomized, double-blind, placebo-controlled trial.
- A. Bohadana, F. Nilsson, T. Rasmussen, Y. Martinet
- Archives of internal medicine
- 13 November 2000
BACKGROUND Nicotine replacement therapy is an effective treatment for nicotine-dependent smokers. However, cessation rates are modest, and preliminary studies suggest that combination therapy may be… Expand
Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis.
- Y. Martinet, W. Rom, Gary R. Grotendorst, G. Martin, R. Crystal
- The New England journal of medicine
- 23 July 1987
Idiopathic pulmonary fibrosis is a fibrotic lung disease characterized by an increased number of mesenchymal cells in the alveolar walls. Alveolar macrophages constitutively express low levels of… Expand
Expression of retinoid receptor genes and proteins in non-small-cell lung cancer.
- E. Picard, C. Seguin, +6 authors J. Vignaud
- Biology, Medicine
- Journal of the National Cancer Institute
- 16 June 1999
BACKGROUND Retinoids can suppress carcinogenesis in high-risk non-neoplastic bronchial lesions and can reduce the risk of second primary non-small-cell lung cancer (NSCLC). The effects of retinoids… Expand
Baseline results of the Depiscan study: a French randomized pilot trial of lung cancer screening comparing low dose CT scan (LDCT) and chest X-ray (CXR).
BACKGROUND Lung cancer has the highest mortality-rate per cancer, with an overall 5-year survival <15%. Several non-randomized studies pointed out the high sensitivity of low dose computed tomography… Expand
Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression.
- A. Kataki, P. Scheid, +4 authors J. Vignaud
- Biology, Medicine
- The Journal of laboratory and clinical medicine
- 1 November 2002
A prerequisite to the developement of an efficient cell and/or gene therapy for lung cancer is a precise characterization of the inflammatory cell populations spontaneously present in the tumor… Expand
Predictive survival markers in patients with surgically resected non-small cell lung carcinoma.
- J. Moldvay, P. Scheid, +12 authors N. Martinet
- Clinical cancer research : an official journal of…
- 1 March 2000
Among patients with resected non-small cell lung carcinoma, about 50% will present a tumor recurrence. Thus, it would be of major importance to be able to predict and try to prevent these relapses by… Expand
The role of platelet-derived growth factor production by tumor-associated macrophages in tumor stroma formation in lung cancer.
Lung cancer is the most common cause of death by cancer in developed countries. Since a tumor cannot develop without the parallel expansion of a tumor stroma, a better understanding of its formation… Expand
Cytokines in human lung fibrosis.
- Y. Martinet, O. Ménard, P. Vaillant, J. Vignaud, N. Martinet
- Archives of toxicology. Supplement. = Archiv fur…
Fibrosis is a pathological process characterized by the replacement of normal tissue by mesenchymal cells and the extracellular matrix produced by these cells. The sequence of events leading to… Expand