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1,6-dinitropyrene

Known as: DINITROPYRENE, 1,6-, Pyrene, 1,6-dinitro- 
A synthetic, yellow crystalline solid that is insoluble in water and moderately soluble in toluene. It is not used for any commercial applications… 
National Institutes of Health

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MutagensPyrenes

Papers overview

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Highly Cited
2012
Highly Cited
2012
A new imidazolium-embedded C18 stationary phase with enhanced performance in reversed-phase liquid chromatography.
2002
2002
Salmonella typhimurium mutagenicity tester strains that overexpress oxygen-insensitive nitroreductases nfsA and nfsB.
Highly Cited
1992
Highly Cited
1992
Genotoxicities of nitropyrenes and their modulation by apigenin, tannic acid, ellagic acid and indole-3-carbinol in the Salmonella and CHO systems.
1990
1990
Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes.
NADPH-fortified human liver microsomes were examined with regard to ability to detoxicate several chemicals that do not require… 
Highly Cited
1988
Highly Cited
1988
DNA binding by 1-nitropyrene and 1,6-dinitropyrene in vitro and in vivo: effects of nitroreductase induction.
1-Nitropyrene, the predominant nitropolycyclic aromatic hydrocarbon found in diesel exhaust, is a mutagen and tumorigen. 1,6… 
1987
1987
Carcinogen-DNA adduct formation in the lungs and livers of preweanling CD-1 male mice following administration of [3H]-6-nitrochrysene, [3H]-6-aminochrysene, and [3H]-1,6-dinitropyrene.
6-Nitrochrysene (NC) and 6-aminochrysene (AC) have been shown to be potent lung and liver carcinogens when administered in… 
1986
1986
Mutagenicity of the photochemical reaction products of pyrene with nitrogen dioxide.
Highly Cited
1986
Highly Cited
1986
Synthesis and mutagenicity of 1-nitro-6-nitrosopyrene and 1-nitro-8-nitrosopyrene, potential intermediates in the metabolic activation of 1,6- and 1,8-dinitropyrene.
1,6-Dinitropyrene and 1,8-dinitropyrene are environmental contaminants which are mutagenic in bacteria and cultured mammalian… 
Highly Cited
1985
Highly Cited
1985
Lung carcinoma induction in Syrian golden hamsters by intratracheal instillation of 1,6-dinitropyrene.
The carcinogenicity of a potent mutagen, 1,6-dinitropyrene (1,6-DNP), was examined by intratracheal instillation into non-inbred… 
Highly Cited
1985
Highly Cited
1985
Identification and quantification of highly mutagenic nitroacetoxypyrenes and nitrohydroxypyrenes in diesel-exhaust particles.
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