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visilizumab

Known as: Anti CD3, Anti-CD3 Antibody 
A humanized, non-Fc receptor (FcR)-binding IgG2 monoclonal antibody (MoAb) directed against CD3 with potential immunosuppressive activity… 
National Institutes of Health

Related topics

Related topics

10 relations

Narrower (2)

Anti-CD3 AntibodyMonoclonal Antibody HuM291

Broader (2)

Antibodies, Monoclonal, HumanizedMonoclonal Antibodies
CD3 AntigensMuromonab-CD3NuvionPositive Regulation of Apoptosis

Papers overview

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Highly Cited
2010
Highly Cited
2010
Prospective randomized open‐label multicenter phase I/II dose escalation trial of visilizumab (HuM291) in severe steroid‐refractory ulcerative colitis†
Background: Visilizumab is a humanized IgG2 monoclonal anti‐CD3 antibody. We evaluated its safety and dose response in severe… 
Highly Cited
2007
Highly Cited
2007
Inhibition of human ovarian tumor growth by cytokine-induced killer cells
Despite the recent improvement in the treatment of ovarian cancer, this disease is still leading cause of cancer death in women… 
Highly Cited
2002
Highly Cited
2002
A humanized non-FcR-binding anti-CD3 antibody, visilizumab, for treatment of steroid-refractory acute graft-versus-host disease.
Visilizumab is a humanized anti-CD3 monoclonal antibody characterized by a mutated IgG2 isotype, lack of binding to Fcgamma… 
Highly Cited
2000
Highly Cited
2000
Calcineurin Is Downstream of the Inositol 1,4,5-Trisphosphate Receptor in the Apoptotic and Cell Growth Pathways*
The inositol 1,4,5-trisphosphate receptor (IP3R) is a calcium (Ca2+) release channel found on the endoplasmic reticulum of… 
Highly Cited
1999
Highly Cited
1999
HuM291, a humanized anti-CD3 antibody, is immunosuppressive to T cells while exhibiting reduced mitogenicity in vitro.
BACKGROUND OKT3, a mouse monoclonal antibody (Ab) specific for the human CD3 complex on T cells, is a potent immunosuppressive… 
Highly Cited
1992
Highly Cited
1992
Freshly isolated, murine neonatal T cells produce IL-4 in response to anti-CD3 stimulation.
In previous studies of chimeric animals, we found that fetal intrathymic T cell precursors give rise to phenotypically abnormal… 
Highly Cited
1990
Highly Cited
1990
Differential regulation of interleukin 4 and interleukin 5 gene expression: a comparison of T-cell gene induction by anti-CD3 antibody or by exogenous lymphokines.
Murine T helper type 2 clones were stimulated with immobilized anti-CD3 antibody or with recombinant lymphokines to compare the… 
Highly Cited
1989
Highly Cited
1989
Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex
In this study, fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system… 
1989
1989
Bivalent binding of an anti-CD3 antibody to Jurkat cells induces association of the T cell receptor complex with the cytoskeleton.
Ligand binding and cross-linking of TCR/CD3 complex leads to T cell stimulation in immunologic responses. As a prelude to… 
Highly Cited
1987
Highly Cited
1987
Activation of T cells by cross‐linking an anti‐CD3 antibody with a second anti‐T cell antibody: mechanism and subset‐specific activation
Binding of anti‐CD3 antibody BMA030‐F(ab′)2 to T cells is not able to induce T cell proliferation even after additional cross… 
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