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Metagenomic Analyses of Alcohol Induced Pathogenic Alterations in the Intestinal Microbiome and the Effect of Lactobacillus rhamnosus GG Treatment
TLDR
Overall, significant alterations in the gut microbiome over time occur in response to chronic alcohol exposure and correspond to increases in intestinal barrier dysfunction and development of ALD. Expand
Green tea polyphenols block endotoxin-induced tumor necrosis factor-production and lethality in a murine model.
TLDR
It is concluded that the anti-inflammatory mechanism of green tea polyphenols is mediated at least in part through down-regulation of TNFalpha gene expression by blocking NF-KB activation. Expand
Nutritional status of patients with amyotrophic lateral sclerosis: relation to the proximity of death.
TLDR
It is concluded that ALS patients have a chronically deficient intake of energy and recommended augmentation of energy intake rather than the consumption of high-protein nutritional supplements. Expand
Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin.
TLDR
The hypothesis that high fructose consumption may not only lead to liver damage through overfeeding but also may be directly pro-inflammatory by increasing intestinal translocation of endotoxin is supported. Expand
Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition.
TLDR
Optimal therapy for NAFLD appears to include lifestyle modification with exercise, diet and weight loss, and certain nutrients may also be of benefit, including certain proinflammatory cytokines, oxidative stress and possibly industrial toxins. Expand
Zinc supplementation is associated with improved neurologic recovery rate and visceral protein levels of patients with severe closed head injury.
TLDR
It is indicated that zinc supplementation during the immediate postinjury period is associated with improved rate of neurologic recovery and visceral protein concentrations for patients with severe closed head injury. Expand
Polychlorinated Biphenyls, Lead, and Mercury Are Associated with Liver Disease in American Adults: NHANES 2003–2004
TLDR
PC, lead, and mercury exposures were associated with unexplained ALT elevation, a proxy marker of NAFLD, in NHANES 2003–2004 adult participants. Expand
Molecular mechanisms of acrolein toxicity: relevance to human disease.
TLDR
This review addresses the current understanding of each pathogenic mechanism of acrolein toxicity, with emphasis on the known and anticipated contribution to clinical disease, and potential therapies. Expand
Gut-liver axis, nutrition, and non-alcoholic fatty liver disease.
TLDR
The concepts addressed in this review have important clinical implications, although more work needs to be done to understand how dietary factors affect the gut barrier and microbiota, and to comprehend how microbe-derived components may interfere with the host's metabolism contributing to NAFLD development. Expand
Antioxidants as novel therapy in a murine model of colitis.
TLDR
Three structurally dissimilar antioxidants provided protection against DSS-induced colitis in this murine model, supporting a possible role for antioxidant therapy in IBD patients. Expand
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