Metagenomic Analyses of Alcohol Induced Pathogenic Alterations in the Intestinal Microbiome and the Effect of Lactobacillus rhamnosus GG Treatment
- Lara M. Bull-Otterson, Wenke Feng, S. Barve
- Medicine, BiologyPLoS ONE
- 9 January 2013
Overall, significant alterations in the gut microbiome over time occur in response to chronic alcohol exposure and correspond to increases in intestinal barrier dysfunction and development of ALD.
Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin.
- I. Bergheim, S. Weber, S. Bischoff
- Medicine, BiologyJournal of Hepatology
- 1 June 2008
Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition.
- M. Cave, I. Deaciuc, C. McClain
- MedicineJournal of Nutritional Biochemistry
- 1 March 2007
Molecular mechanisms of acrolein toxicity: relevance to human disease.
- A. Moghe, Smita S. Ghare, S. Joshi‐Barve
- Biology, MedicineToxicological Sciences
- 1 February 2015
This review addresses the current understanding of each pathogenic mechanism of acrolein toxicity, with emphasis on the known and anticipated contribution to clinical disease, and potential therapies.
Polychlorinated Biphenyls, Lead, and Mercury Are Associated with Liver Disease in American Adults: NHANES 2003–2004
- M. Cave, Savitri N. Appana, Mihir K. Patel, K. Falkner, C. McClain, G. Brock
- MedicineEnvironmental Health Perspectives
- 3 September 2010
PC, lead, and mercury exposures were associated with unexplained ALT elevation, a proxy marker of NAFLD, in NHANES 2003–2004 adult participants.
Green tea polyphenols block endotoxin-induced tumor necrosis factor-production and lethality in a murine model.
- F. Yang, W. D. de Villiers, C. McClain, G. Varilek
- BiologyJournal of NutriLife
- 1 December 1998
It is concluded that the anti-inflammatory mechanism of green tea polyphenols is mediated at least in part through down-regulation of TNFalpha gene expression by blocking NF-KB activation.
Nutritional status of patients with amyotrophic lateral sclerosis: relation to the proximity of death.
- E. Kasarskis, S. Berryman, J. Vanderleest, A. Schneider, C. McClain
- MedicineAmerican Journal of Clinical Nutrition
It is concluded that ALS patients have a chronically deficient intake of energy and recommended augmentation of energy intake rather than the consumption of high-protein nutritional supplements.
Increased tumor necrosis factor production by monocytes in alcoholic hepatitis
- C. McClain, D. Cohen
- 1 March 1989
Monocytes from alcoholic hepatitis patients have significantly increased spontaneous and lipopolysaccharide‐stimulated tumor necrosis factor release compared to monocytes from healthy volunteers, suggesting that some of the metabolic abnormalities and possibly some ofThe liver injury of alcoholic hepatitis may be due to enhanced tumor Necrosis factor production.
Cytokines in alcoholic liver disease.
- C. McClain, S. Barve, I. Deaciuc, M. Kugelmas, D. Hill
- Medicine, BiologySeminars in liver disease (Print)
There is an emerging rationale for use of anticytokine therapy in alcoholic liver disease, with the goal of maintaining beneficial effects of cytokines and inhibition of the deleterious effects of these potentially toxic agents.
Gut-liver axis, nutrition, and non-alcoholic fatty liver disease.
- I. Kirpich, L. Marsano, C. McClain
- Medicine, BiologyClinical Biochemistry
- 1 September 2015