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- Publications
- Influence
Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles
- T. Baumgart, A. Hammond, +4 authors W. Webb
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 27 February 2007
The membrane raft hypothesis postulates the existence of lipid bilayer membrane heterogeneities, or domains, supposed to be important for cellular function, including lateral sorting, signaling, and… Expand
Bimolecular Fluorescence Complementation ( BiFC ) Analysis as a Probe of Protein Interactions in Living Cells
Protein interactions are a fundamental mechanism for the generation of biological regulatory specificity. The study of protein interactions in living cells is of particular significance because the… Expand
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Critical fluctuations in plasma membrane vesicles.
- S. Veatch, P. Cicuta, P. Sengupta, Aurelia R. Honerkamp-Smith, D. Holowka, B. Baird
- Chemistry, Medicine
- ACS chemical biology
- 16 May 2008
We demonstrate critical behavior in giant plasma membrane vesicles (GPMVs) that are isolated directly from living cells. GPMVs contain two liquid phases at low temperatures and one liquid phase at… Expand
Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells
- M. Antonyak, B. Li, +5 authors R. Cerione
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 28 February 2011
Tumor progression involves the ability of cancer cells to communicate with each other and with neighboring normal cells in their microenvironment. Microvesicles (MV) derived from human cancer cells… Expand
Crosslinking a lipid raft component triggers liquid ordered-liquid disordered phase separation in model plasma membranes.
- A. Hammond, F. Heberle, T. Baumgart, D. Holowka, B. Baird, G. Feigenson
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 3 May 2005
The mechanisms by which a cell uses and adapts its functional membrane organization are poorly understood and are the subject of ongoing investigation and discussion. Here, we study one proposed… Expand
A Lipid Raft Environment Enhances Lyn Kinase Activity by Protecting the Active Site Tyrosine from Dephosphorylation*
- R. Young, D. Holowka, B. Baird
- Biology, Medicine
- Journal of Biological Chemistry
- 6 June 2003
The plasma membrane contains ordered lipid domains, commonly called lipid rafts, enriched in cholesterol, sphingolipids, and certain signaling proteins. Lipid rafts play a structural role in signal… Expand
Compartmentalized Activation of the High Affinity Immunoglobulin E Receptor within Membrane Domains*
- K. Field, D. Holowka, B. Baird
- Biology, Medicine
- The Journal of Biological Chemistry
- 14 February 1997
The earliest known step in the activation of the high affinity IgE receptor, FcεRI, is the tyrosine phosphorylation of its β and γ subunits by the Src family tyrosine kinase, Lyn. We report here that… Expand
Correlation Functions Quantify Super-Resolution Images and Estimate Apparent Clustering Due to Over-Counting
- S. Veatch, Benjamin B. Machta, Sarah A. Shelby, Ethan N. Chiang, D. Holowka, B. Baird
- Physics, Biology
- PloS one
- 29 June 2011
We present an analytical method using correlation functions to quantify clustering in super-resolution fluorescence localization images and electron microscopy images of static surfaces in two… Expand
Fluorescence anisotropy measurements of lipid order in plasma membranes and lipid rafts from RBL-2H3 mast cells.
- A. Gidwani, D. Holowka, B. Baird
- Chemistry, Medicine
- Biochemistry
- 18 September 2001
Specialized plasma membrane domains known as lipid rafts participate in signal transduction and other cellular processes, and their liquid ordered (L(o)) phase appears to be important for their… Expand
Structural determinants for partitioning of lipids and proteins between coexisting fluid phases in giant plasma membrane vesicles.
- P. Sengupta, A. Hammond, D. Holowka, B. Baird
- Chemistry, Medicine
- Biochimica et biophysica acta
- 2008
The structural basis for organizational heterogeneity of lipids and proteins underlies fundamental questions about the plasma membrane of eukaryotic cells. A current hypothesis is the participation… Expand