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Muromonab-CD3

Known as: Anti-CD3 monoclonal antibody OKT 3, Anti-CD3 monoclonal antibody OKT3, Anti-CD3 
A murine IgG2a monoclonal antibody with immunosuppressive activity. Muromonab-CD3 binds to and inhibits CD3 on the surface of circulating T… 
National Institutes of Health

Related topics

Related topics

17 relations
CD3 AntigensDecreased Immunologic Activity [PE]Drug AllergyEdema

Broader (2)

Immunologic FactorsImmunosuppressive Agents

Narrower (2)

OrthoclonehOKT3 gamma4

Papers overview

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Highly Cited
1993
Highly Cited
1993
Specific interaction of lymphocyte function-associated antigen 3 with CD2 can inhibit T cell responses
Accessory cell surface molecules, such as T cell antigen CD2 and its ligand lymphocyte function-associated antigen 3 (LFA-3; CD58… 
Highly Cited
1989
Highly Cited
1989
Soluble CD8 during T cell activation.
The CD8 Ag has long been used as a surface marker for the identification of cytotoxic and suppressor cells. Recently CD8-positive… 
Highly Cited
1988
Highly Cited
1988
Two subsets of human T lymphocytes expressing gamma/delta antigen receptor are identifiable by monoclonal antibodies directed to two distinct molecular forms of the receptor
Two mAbs directed to the TCR-gamma/delta were analyzed for their pattern of reactivity with CD3+WT31- cell populations or clones… 
Highly Cited
1986
Highly Cited
1986
The AMeX method. A simplified technique of tissue processing and paraffin embedding with improved preservation of antigens for immunostaining.
A new simplified tissue processing method for immunostaining was devised. Tissues were fixed in acetone at -20 C overnight, then… 
Highly Cited
1985
Highly Cited
1985
Perturbation of the T4 molecule transmits a negative signal to T cells
We investigated the functional role of the T4 molecule in the activation of T cells by OKT3. T4+ cells were induced to… 
Highly Cited
1983
Highly Cited
1983
Lymphocyte subsets in normal human lymphoid tissues.
A series of B, T, natural killer (NK) cell, and monocyte-specific monoclonal antibodies was used to determine the localization of… 
Highly Cited
1982
Highly Cited
1982
Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens
A recently described HLA gene, SB, which maps between GLO and HLA-DR, codes for Ia-like molecules that are similar to but… 
Highly Cited
1982
Highly Cited
1982
Selective inhibition of human T cell cytotoxicity at levels of target recognition or initiation of lysis by monoclonal OKT3 and Leu-2a antibodies
Out of a panel of seven monoclonal antibodies with affinity for human lymphoid cells, three were shown to prevent cytotoxic T… 
Highly Cited
1980
Highly Cited
1980
Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison
Human T cell subpopulations have been defined on the basis of differential expression of either Fc receptors or specific cell… 
Highly Cited
1980
Highly Cited
1980
OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties.
OKT3, a monoclonal anti-human T cell antibody (IgG2), was found to induce DNA synthesis in human peripheral lymphocyte cultures… 
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