Antibodies, Monoclonal, Humanized
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Monoclonal antibodies represent an attractive therapeutic tool as they are highly specific for their targets, convey effector… Expand Targeted gene disruption in rats paves the way for new human disease models. The toolbox of rat genetics currently lacks the… Expand Nanoscience and Nanotechnology have found their way into the fields of Biotechnology and Medicine. Nanoparticles by themselves… Expand Purpose: A significant fraction of HER2-overexpressing breast cancers exhibit resistance to the HER2 antibody trastuzumab… Expand The glycated form of a basic recombinant humanized monoclonal antibody (rhuMAb) was separated and quantitated by boronate… Expand We have identified a single tryptophan (Trp) residue responsible for loss of binding and biological activity upon ultraviolet (UV… Expand Conjugates of the anti-CanAg humanized monoclonal antibody huC242 with the microtubule-formation inhibitor DM1 (a maytansinoid… Expand Antibodies and small molecule tyrosine kinase inhibitors targeting ErbB2 exhibit distinct, noncross resistant mechanisms of… Expand The HER family of transmembrane tyrosine kinase receptors is composed of four members, BER1 to HER4. HER2 is a ligand-orphan… Expand Antibody therapy holds great promise for the treatment of cancer, autoimmune disorders, and viral infections. Murine monoclonal… Expand