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ubenimex

Known as: L-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-, N-[(2S,3R)-4-phenyl-3-amino-2-hydroxybutyryl]-L-leucine, (3-amino-2-hydroxy-4-phenylbutanoyl)-L-leucine 
A microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Ubenimex competitively inhibits many aminopeptidases… 
National Institutes of Health

Related topics

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9 relations

Broader (7)

Anti-Bacterial AgentsAnti-HIV AgentsAntibiotics, AntineoplasticImmunologic Adjuvants
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

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Highly Cited
1992
Highly Cited
1992
Bradykinin‐induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord‐tail preparation in vitro
1 The effects of bradykinin on nociceptors have been characterized on a preparation of the neonatal rat spinal cord with… 
Highly Cited
1989
Highly Cited
1989
Inhibition of aminopeptidases by aminophosphonates.
More than 30 aminophosphonates were synthesized to probe how the structural changes introduced into the phosphonic acid analogue… 
Highly Cited
1989
Highly Cited
1989
Purification of Two Dipeptidyl Aminopeptidases II from Rat Brain and Their Action on Proline‐Containing Neuropeptides
Abstract From the soluble and membrane fractions of rat brain homogenate, two enzymes that liberate dipeptides of the type Xaa… 
Highly Cited
1985
Highly Cited
1985
Identification of aminopeptidase M as an enkephalin-inactivating enzyme in rat cerebral membranes.
Two membrane-bound enkephalin-hydrolyzing aminopeptidase activities were partially purified from rat brain membranes. The first… 
Highly Cited
1985
Highly Cited
1985
The slow, tight binding of bestatin and amastatin to aminopeptidases.
Highly Cited
1983
Highly Cited
1983
Participation of both ‘enkephalinase’ and aminopeptidase activities in the metabolism of endogenous enkephalins
Highly Cited
1980
Highly Cited
1980
Effect of bestatin on mouse immune system and experimental murine tumors.
Effect of bestatin on the establishment of delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC) and oxazolone was… 
Highly Cited
1979
Highly Cited
1979
Restoration of impaired immune functions of aged animals by chronic bestatin treatment.
An attempt to correct the state of immunodeficiency in old age was made by repeatedly injecting a chemically defined… 
Highly Cited
1976
Highly Cited
1976
Inhibition of aminopeptidase B and leucine aminopeptidase by bestatin and its stereoisomer.
Highly Cited
1976
Highly Cited
1976
Aminopeptidase activities on the surface of mammalian cells.
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