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Tetrahydropyranyl derivatives of daunomycin and adriamycin.
Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity.
New anthracycline antibiotics have been isolated from the culture of Streptomyces galilaeus MA144-M1 and aclacinomycin-A showed the strongest activity in inhibiting leukemia L-1210 and had lower toxicity than others.
Cyclic AMP and immune responses. II. Phosphodiesterase inhibitors as potentiators of polynucleotide effects on antibody formation.
The stimulatory effects of theophylline and caffeine, both known stabilizers of cAMP levels, further support the conclusion that cAMP-mediated events are a critical component of the activation and regulation of immunocompetent cells.
Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell‐induced angiogenesis
- K. Minamiguchi, H. Kumagai, T. Masuda, M. Kawada, M. Ishizuka, T. Takeuchi
- Biology, MedicineInternational journal of cancer
- 1 August 2001
Thiolutin, an inhibitor of HUV EC adhesion to vitronectin, reduces the paxillin level in HUVECs and suppresses tumor cell‐induced angiogenesis in vivo.
Metacytofilin, a novel immunomodulator produced by Metarhizium sp. TA2759.
Studies on bleomycin
- H. Umezawa, M. Ishizuka, K. Maeda, T. Takeuchi
- Biology, MedicineTaiwan yi xue hui za zhi. Journal of the Formosan…
- 28 November 1969
Bleomycin A, which is a complex of water‐soluble peptides produced by a Streptomyces, inhibits DNA synthesis in intact cells of E. coli and HeLa cells and also inhibits Ehrlich carcinoma and Sarcoma 180 gives curative effect on a skin cancer in a dog.
A new antitumor antibiotic, spergualin: isolation and antitumor activity.
The antibiotic produced by a bacillus isolated from a soil sample collected at Ohira-san, Tochigi Prefecture had a low toxicity and exhibited a marked effect against mouse L-1210 leukemia and was named spergualin.
Cyclic AMP and immune responses. I. Influence of poly A:U and cAMP on antibody formation in vitro.
The modification of antibody formation in vitro can be attributed to an alteration of cyclic AMP-mediated events, particularly since cAMP itself as well as the supplementation of poly A:U with theophylline can increase the number of antibody-forming cells that can be activated in vitro in the presence of a given amount of antigen.
Cyclic AMP Effects on Antibody Formation and Their Similarities to Hormone-Mediated Events 1
Summary Cyclic AMP enhances antibody formation in vivo and in vitro as judged by tests in which sheep red blood cells served as antigen and the effects were measured by determining the early rate of…
Antibody formation: reduced responses after administration of excessive amounts of nonspecific stimulators.
D dose-response relationships may be pertinent to an understanding of phenomena of specific immunological nonresponsiveness and certain types of antigenic competition.