H. Umezawa

Publications1,283
h-index74
Citations26,452
Highly Influential Citations216
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Formation and reversion of Streptomycete protoplasts: cultural condition and morphological study.
TLDR
Combinations of appropriate concentrations of MgCl2 and CaCl2 were significantly effective in the reversion as well as in the stability of protoplasts.
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New antibiotics, bleomycin A and B.
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Structures and activities of protease inhibitors of microbial origin.
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Pepstatin, a new pepsin inhibitor produced by Actinomycetes.
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Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus
TLDR
The results suggest that benzoquinonoid ansamycins have no direct effect on src kinase but destroy its intracellular environment, resulting in an irreversible alteration of p60src and loss of catalytic activity.
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Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria.
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A plasmid involved in chloramphenicol production in Streptomyces venezuelae: evidence from genetic mapping.
TLDR
It is concluded that chloramphenicol production is controlled by a plasmid that appeared to be non-transferable in conjugation.
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Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes.
papain, chymotrypsin, elastase, acid protease and thermolysin have been found in culture filtrates of actinomycetes. Recently we found that exopeptidases have a strong effect on mammalian cell…
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Low-molecular-weight enzyme inhibitors of microbial origin.
  • H. Umezawa
  • Biology
    Annual review of microbiology
  • 1982
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Recent advances in bioactive microbial secondary metabolites.
  • H. Umezawa
  • Engineering
    The Japanese journal of antibiotics
  • 1 December 1977
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