H. Umezawa

Publications1,286
h-index73
Citations25,336
Highly Influential Citations197
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Formation and reversion of Streptomycete protoplasts: cultural condition and morphological study.
Cultural conditions for forming and stabilizing protoplasts of Streptomyces griseus and S. venezuelae were studied by reference to the number of protoplasts formed, leakage from protoplasts and… Expand
New antibiotics, bleomycin A and B.
Pepstatin, a new pepsin inhibitor produced by Actinomycetes.
Structures and activities of protease inhibitors of microbial origin.
  • H. Umezawa
  • Biology, Medicine
  • Methods in enzymology
  • 1976
Publisher Summary Compared with inhibitors obtained from animal and plant tissues, which are mostly of macromolecular nature, the enzyme inhibitors found in microbial culture filtrates are relatively… Expand
Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus.
Three benzenoid ansamycin antibiotics (herbimycin, macbecin, and geldanamycin) were found to reduce the intracellular phosphorylation of p60src at a permissive temperature (33 degrees C) in a rat… Expand
Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria.
Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes.
papain, chymotrypsin, elastase, acid protease and thermolysin have been found in culture filtrates of actinomycetes. Recently we found that exopeptidases have a strong effect on mammalian cell… Expand
Low-molecular-weight enzyme inhibitors of microbial origin.
  • H. Umezawa
  • Chemistry, Medicine
  • Annual review of microbiology
  • 1982
A plasmid involved in chloramphenicol production in Streptomyces venezuelae: evidence from genetic mapping.
To test the hypothesis that chloramphenicol production in Streptomyces venezuelae depends on the presence of a plasmid, mapping analysis was carried out by using eight markers in addition to… Expand
Tetrahydropyranyl derivatives of daunomycin and adriamycin.
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