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Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus.
TLDR
A potent tyrosine kinase inhibitor, lavendustin A, has been isolated from a butyl acetate extract of Streptomyces griseolavendus culture filtrate, and its structure is novel, having a tertiary amine in the center with substituted benzyl and phenyl groups. Expand
New antibiotics, bleomycin A and B.
Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes.
papain, chymotrypsin, elastase, acid protease and thermolysin have been found in culture filtrates of actinomycetes. Recently we found that exopeptidases have a strong effect on mammalian cellExpand
Leupeptins, new protease inhibitors from Actinomycetes.
Inhibition of epidermal growth factor‐induced DNA synthesis by tyrosine kinase inhibitors
TLDR
Methyl 2,5‐dihydroxycinnamate was shown to delay the S‐phase induction by epidermal growth factor in quiescent normal rat kidney cells, without affecting the total amount ofDNA synthesis. Expand
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy, isolation, and characterization.
TLDR
A novel inhibitor of protein tyrosine phosphatase, dephostatin, was isolated from the culture broth of a strain of Streptomyces and inhibited the growth of Jurkat cells. Expand
TAXONOMY , PRODUCTION , ISOLATION , PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES
Benastatins have been isolated as part of a program designed to find microorganism-produced inhibitors of glutathione S-transferase from Streptomyces sp. MI384-DF12. They were purified byExpand
Tetrahydropyranyl derivatives of daunomycin and adriamycin.
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