Bradykinin and inflammatory pain
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid
Antihyperalgesic effects of delta opioid agonists in a rat model of chronic inflammation.
- G. Fraser, G. Gaudreau, P. Clarke, D. Ménard, M. Perkins
- Biology, MedicineBritish Journal of Pharmacology
The results indicate that mu and delta opioid receptors in the brain modulate descending pain pathways to attenuate the nociceptive response to acute thermal stimuli in both normal and inflamed tissues.
Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS.
Kinins and kinin receptors in the nervous system
Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus
It is found that electrical stimulation of this area produced increased BAT thermogenesis, which suggests that the VMH exerts a dual influence in the regulation of energy balance—an inhibitory effect on energy intake and a stimulatory effect on thermogenesis and energy output.
Pro-nociceptive effects of neuromedin u in rat
Antinociceptive activity of the bradykinin B1 and B2 receptor antagonists, des-Arg9, [Leu8]-BK and HOE 140, in two models of persistent hyperalgesia in the rat
Antihyperalgesic effects of δ opioid agonists in a rat model of chronic inflammation
The results indicate that μ and δ opioid receptors in the brain modulate descending pain pathways to attenuate the nociceptive response to acute thermal stimuli in both normal and inflamed tissues.
The involvement of bradykinin B1 and B2 receptor mechanisms in cytokine‐induced mechanical hyperalgesia in the rat
The data suggest that both bradykinin B1 and B2 receptors are involved in the induction and maintenance of cytokine‐induced hyperalgesia and show that the induction of B1 receptor‐mediated hyperAlgesia requires both cyclo‐oxygenase products and IL‐1 in vivo.