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Organophosphonate Utilization by the Wild-Type Strain of Penicillium notatum.
It is found that a wild-type strain of Penicillium notatum is able to utilize structurally diverse organophosphonates as sole sources of phosphorus, and this ability seems to be inducible, as indicated by the presence of a lag phase during growth. Expand
Inhibition of aminopeptidases by aminophosphonates.
The most effective inhibitor was [1-amino-2-(N-cyclohexylamino)ethyl]phosphonic acid, which has a Ki value of 0.87 microM toward the microsomal aminopeptidase--a value that can be considered as equipotent with bestatin and with leucinal and hydroxamic acids, the strongest known nonpeptide inhibitors of this enzyme. Expand
The ability of soil-borne fungi to degrade organophosphonate carbon-to-phosphorus bonds
Abstract The ability of a wide variety of soil-borne fungal strains to degrade four structurally different com pounds containing PC bonds, namely the naturally occurring amino acid ciliatine, theExpand
Comparative study of fungal cell disruption—scope and limitations of the methods
The mechanical methods of disintegration appeared to be the most effective for the disintegration of yeast, R. gracilis, and filamentous fungi, A. fumigatus and P. citrinum. Expand
Degradation of phosphonates by streptomycete isolates
Streptomycete StC had a surprising ability to degrade N-phosphonomethylglycine (glyphosate) in a phosphate-independent manner via C–P bond cleavage accompanied by sarcosine formation. Expand
Abstract Aminophosphonates are analogues of amino acids in which a carboxylic moiety is replaced by phosphonic acid or related groups. Acting as antagonists of amino acids, they inhibit enzymesExpand
Aminophosphonic acids of potential medical importance.
Aminophosphonic acids were almost unknown in 1959 but today they are the subject of more than 6000 papers, and represent promising and somewhat undiscovered class of potential drugs. Expand
Organophosphonate Utilization by the Thermophile Geobacillus caldoxylosilyticus T20
ABSTRACT A strain of Geobacillus caldoxylosilyticus from central heating system water could utilize a number of organophosphonates as the sole phosphorus source for growth at 60°C. During growth onExpand
Phosphonic analogues of tyrosine and 3,4-dihydroxyphenylalanine (dopa) influence mushroom tyrosinase activity.
Shortening of the alkyl chain by one methylene group gave amino-(3,4-dihydroxyphenyl)methylphosphonic acid, one of the most powerful known inhibitors of this enzyme. Expand